CYBB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	39 studies	55% ± 18%	Explore
classical monocyte	28 studies	67% ± 17%	Explore
non-classical monocyte	24 studies	72% ± 12%	Explore
conventional dendritic cell	23 studies	35% ± 15%	Explore
B cell	22 studies	27% ± 7%	Explore
monocyte	22 studies	57% ± 16%	Explore
memory B cell	19 studies	26% ± 6%	Explore
plasmacytoid dendritic cell	19 studies	56% ± 13%	Explore
dendritic cell	16 studies	31% ± 10%	Explore
naive B cell	16 studies	26% ± 6%	Explore
myeloid cell	16 studies	49% ± 20%	Explore
microglial cell	10 studies	42% ± 15%	Explore
alveolar macrophage	6 studies	59% ± 16%	Explore
neutrophil	6 studies	43% ± 15%	Explore
mononuclear phagocyte	5 studies	50% ± 16%	Explore
intermediate monocyte	5 studies	69% ± 9%	Explore
leukocyte	4 studies	31% ± 9%	Explore
immature B cell	3 studies	33% ± 3%	Explore
tissue-resident macrophage	3 studies	53% ± 15%	Explore
inflammatory macrophage	3 studies	50% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	25% ± 6%	Explore
lung	6 studies	21% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	5781.49	574 / 578	91%	68.43	1051 / 1155
breast	77%	1074.66	353 / 459	91%	52.91	1020 / 1118
intestine	87%	1789.28	843 / 966	71%	28.67	373 / 527
bladder	90%	1151.24	19 / 21	61%	31.79	307 / 504
stomach	57%	643.88	204 / 359	78%	37.85	224 / 286
adrenal gland	91%	2202.05	234 / 258	39%	8.51	90 / 230
brain	40%	538.20	1059 / 2642	89%	55.59	625 / 705
esophagus	54%	639.63	783 / 1445	72%	22.06	132 / 183
ovary	42%	411.19	75 / 180	77%	34.91	330 / 430
kidney	39%	526.27	35 / 89	79%	52.02	712 / 901
thymus	44%	511.38	289 / 653	72%	23.65	434 / 605
pancreas	32%	326.15	106 / 328	82%	39.55	146 / 178
prostate	61%	621.58	150 / 245	51%	11.83	256 / 502
uterus	42%	388.29	72 / 170	66%	22.60	304 / 459
lymph node	0%	0	0 / 0	100%	253.74	29 / 29
peripheral blood	100%	13052.91	929 / 929	0%	0	0 / 0
spleen	100%	10056.12	241 / 241	0%	0	0 / 0
adipose	94%	2774.48	1133 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	47.54	38 / 45
skin	9%	76.50	170 / 1809	72%	44.47	341 / 472
liver	35%	360.98	78 / 226	36%	10.68	148 / 406
blood vessel	67%	1146.87	899 / 1335	0%	0	0 / 0
heart	46%	538.27	397 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	20%	4.11	16 / 80
muscle	7%	51.16	55 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0045730	Biological process	respiratory burst
GO_0006954	Biological process	inflammatory response
GO_0097411	Biological process	hypoxia-inducible factor-1alpha signaling pathway
GO_0071361	Biological process	cellular response to ethanol
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0045087	Biological process	innate immune response
GO_0042554	Biological process	superoxide anion generation
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0071276	Biological process	cellular response to cadmium ion
GO_1904845	Biological process	cellular response to L-glutamine
GO_0050665	Biological process	hydrogen peroxide biosynthetic process
GO_1904044	Biological process	response to aldosterone
GO_0006801	Biological process	superoxide metabolic process
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_1990776	Biological process	response to angiotensin
GO_0006952	Biological process	defense response
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0034702	Cellular component	monoatomic ion channel complex
GO_0097038	Cellular component	perinuclear endoplasmic reticulum
GO_0043020	Cellular component	NADPH oxidase complex
GO_0043025	Cellular component	neuronal cell body
GO_0005635	Cellular component	nuclear envelope
GO_0030425	Cellular component	dendrite
GO_0070821	Cellular component	tertiary granule membrane
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0009055	Molecular function	electron transfer activity
GO_0020037	Molecular function	heme binding
GO_0046872	Molecular function	metal ion binding
GO_0016175	Molecular function	superoxide-generating NAD(P)H oxidase activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYBB
Protein name	Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) Cytochrome b-245 beta chain Cytochrome b-245 beta polypeptide isoform 2 Cytochrome b-245 heavy chain (CGD91-phox) (Cytochrome b(558) subunit beta) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB Cytochrome b-245 heavy chain Microbicidal oxidase
Synonyms	NOX2
Description	FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Accessions	ENST00000696170.1 A0A8Q3SIJ1 V9GZH6 A0A0S2Z4A9 A0A8G0YK19 P04839 A0A8Q3SIF1 A0A8G0YK02 A0A0S2Z3S6 ENST00000378588.5 V9GZN7 ENST00000696171.1 A0A8Q3WMA3 ENST00000696172.1 G8Z8Y8

CYBB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review