FOS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	50 studies	62% ± 25%	Explore
fibroblast	46 studies	61% ± 27%	Explore
endothelial cell	45 studies	55% ± 28%	Explore
natural killer cell	42 studies	55% ± 21%	Explore
B cell	41 studies	48% ± 21%	Explore
T cell	37 studies	50% ± 23%	Explore
CD8-positive, alpha-beta T cell	36 studies	50% ± 22%	Explore
pericyte	34 studies	68% ± 26%	Explore
conventional dendritic cell	32 studies	80% ± 18%	Explore
smooth muscle cell	31 studies	60% ± 27%	Explore
CD4-positive, alpha-beta T cell	31 studies	58% ± 23%	Explore
dendritic cell	30 studies	64% ± 24%	Explore
classical monocyte	29 studies	83% ± 17%	Explore
non-classical monocyte	28 studies	74% ± 24%	Explore
mast cell	26 studies	61% ± 23%	Explore
monocyte	26 studies	67% ± 21%	Explore
plasma cell	26 studies	50% ± 20%	Explore
regulatory T cell	24 studies	52% ± 24%	Explore
endothelial cell of lymphatic vessel	23 studies	65% ± 22%	Explore
plasmacytoid dendritic cell	23 studies	66% ± 19%	Explore
epithelial cell	23 studies	62% ± 24%	Explore
mature NK T cell	22 studies	55% ± 18%	Explore
basal cell	22 studies	59% ± 24%	Explore
gamma-delta T cell	20 studies	60% ± 21%	Explore
memory B cell	19 studies	52% ± 21%	Explore
naive B cell	19 studies	56% ± 20%	Explore
connective tissue cell	19 studies	70% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	66% ± 23%	Explore
neutrophil	17 studies	71% ± 20%	Explore
endothelial cell of artery	17 studies	53% ± 21%	Explore
myeloid cell	17 studies	61% ± 27%	Explore
ciliated cell	16 studies	59% ± 23%	Explore
mucosal invariant T cell	15 studies	66% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	51% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	58% ± 22%	Explore
capillary endothelial cell	15 studies	47% ± 20%	Explore
vein endothelial cell	15 studies	50% ± 22%	Explore
astrocyte	14 studies	41% ± 26%	Explore
endothelial cell of vascular tree	14 studies	59% ± 24%	Explore
innate lymphoid cell	13 studies	64% ± 20%	Explore
myofibroblast cell	13 studies	77% ± 17%	Explore
goblet cell	13 studies	60% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	47% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	55% ± 22%	Explore
secretory cell	12 studies	58% ± 23%	Explore
microglial cell	12 studies	38% ± 25%	Explore
mesothelial cell	12 studies	74% ± 25%	Explore
type II pneumocyte	11 studies	62% ± 21%	Explore
type I pneumocyte	9 studies	57% ± 23%	Explore
club cell	9 studies	55% ± 27%	Explore
plasmablast	9 studies	54% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	66% ± 23%	Explore
leukocyte	9 studies	60% ± 19%	Explore
erythrocyte	9 studies	38% ± 23%	Explore
progenitor cell	9 studies	65% ± 23%	Explore
T follicular helper cell	9 studies	61% ± 26%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	63% ± 21%	Explore
alveolar macrophage	8 studies	64% ± 22%	Explore
respiratory goblet cell	8 studies	49% ± 28%	Explore
mononuclear phagocyte	8 studies	67% ± 20%	Explore
abnormal cell	8 studies	63% ± 19%	Explore
IgA plasma cell	8 studies	50% ± 23%	Explore
IgG plasma cell	8 studies	50% ± 22%	Explore
ionocyte	7 studies	56% ± 24%	Explore
platelet	7 studies	41% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	38% ± 12%	Explore
enterocyte	7 studies	55% ± 24%	Explore
hematopoietic stem cell	7 studies	69% ± 24%	Explore
precursor B cell	7 studies	54% ± 18%	Explore
immature B cell	7 studies	75% ± 11%	Explore
CD4-positive helper T cell	6 studies	58% ± 23%	Explore
hematopoietic precursor cell	6 studies	63% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	49% ± 22%	Explore
renal alpha-intercalated cell	6 studies	63% ± 20%	Explore
enteroendocrine cell	6 studies	67% ± 19%	Explore
transit amplifying cell	6 studies	54% ± 25%	Explore
intermediate monocyte	6 studies	86% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	28% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	58% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	49% ± 8%	Explore
duct epithelial cell	5 studies	44% ± 21%	Explore
oligodendrocyte precursor cell	5 studies	43% ± 26%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	65% ± 23%	Explore
epithelial cell of proximal tubule	5 studies	39% ± 23%	Explore
renal principal cell	5 studies	53% ± 26%	Explore
pro-B cell	5 studies	45% ± 19%	Explore
glial cell	5 studies	69% ± 10%	Explore
group 3 innate lymphoid cell	5 studies	86% ± 13%	Explore
adventitial cell	5 studies	69% ± 26%	Explore
Mueller cell	5 studies	51% ± 24%	Explore
inflammatory macrophage	5 studies	61% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	42% ± 27%	Explore
adipocyte	5 studies	30% ± 14%	Explore
granulocyte	5 studies	73% ± 19%	Explore
melanocyte	5 studies	49% ± 18%	Explore
deuterosomal cell	4 studies	35% ± 6%	Explore
pancreatic A cell	4 studies	61% ± 15%	Explore
type B pancreatic cell	4 studies	54% ± 17%	Explore
parietal epithelial cell	4 studies	46% ± 20%	Explore
intestinal crypt stem cell	4 studies	71% ± 14%	Explore
kidney loop of Henle epithelial cell	4 studies	50% ± 19%	Explore
Schwann cell	4 studies	62% ± 30%	Explore
T-helper 17 cell	4 studies	82% ± 14%	Explore
neuron	4 studies	47% ± 21%	Explore
retinal pigment epithelial cell	4 studies	63% ± 27%	Explore
acinar cell	4 studies	42% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 27%	Explore
mucus secreting cell	4 studies	41% ± 26%	Explore
keratinocyte	4 studies	60% ± 20%	Explore
hillock cell	3 studies	34% ± 10%	Explore
precursor cell	3 studies	75% ± 7%	Explore
squamous epithelial cell	3 studies	47% ± 22%	Explore
pancreatic D cell	3 studies	68% ± 20%	Explore
monocyte-derived dendritic cell	3 studies	76% ± 25%	Explore
glomerular endothelial cell	3 studies	65% ± 13%	Explore
kidney connecting tubule epithelial cell	3 studies	73% ± 21%	Explore
podocyte	3 studies	87% ± 5%	Explore
paneth cell	3 studies	77% ± 14%	Explore
retinal ganglion cell	3 studies	36% ± 6%	Explore
extravillous trophoblast	3 studies	92% ± 6%	Explore
placental villous trophoblast	3 studies	73% ± 14%	Explore
lymphocyte	3 studies	60% ± 25%	Explore
brush cell	3 studies	60% ± 23%	Explore
amacrine cell	3 studies	34% ± 15%	Explore
retinal cone cell	3 studies	29% ± 11%	Explore
retinal rod cell	3 studies	39% ± 7%	Explore
tissue-resident macrophage	3 studies	75% ± 27%	Explore
intraepithelial lymphocyte	3 studies	56% ± 3%	Explore
erythroblast	3 studies	44% ± 29%	Explore
chondrocyte	3 studies	53% ± 30%	Explore
muscle cell	3 studies	60% ± 12%	Explore
germinal center B cell	3 studies	36% ± 8%	Explore
myoepithelial cell	3 studies	64% ± 25%	Explore
luminal cell of prostate epithelium	3 studies	32% ± 11%	Explore
pancreatic ductal cell	3 studies	55% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	87% ± 5%	Explore
hepatocyte	3 studies	21% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	62% ± 32%	Explore
double negative thymocyte	3 studies	65% ± 20%	Explore
double-positive, alpha-beta thymocyte	3 studies	68% ± 25%	Explore
progenitor cell of mammary luminal epithelium	3 studies	73% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	55% ± 21%	Explore
lung	19 studies	57% ± 19%	Explore
intestine	13 studies	63% ± 26%	Explore
kidney	9 studies	52% ± 22%	Explore
brain	7 studies	32% ± 14%	Explore
eye	7 studies	45% ± 12%	Explore
liver	6 studies	36% ± 17%	Explore
lymph node	6 studies	63% ± 21%	Explore
pancreas	5 studies	54% ± 18%	Explore
uterus	5 studies	82% ± 15%	Explore
placenta	4 studies	67% ± 25%	Explore
bone marrow	4 studies	52% ± 23%	Explore
esophagus	4 studies	47% ± 27%	Explore
prostate	4 studies	33% ± 5%	Explore
skin	4 studies	56% ± 19%	Explore
breast	4 studies	68% ± 17%	Explore
ovary	3 studies	52% ± 27%	Explore
heart	3 studies	18% ± 2%	Explore
adipose	3 studies	50% ± 21%	Explore
adrenal gland	3 studies	53% ± 23%	Explore
stomach	3 studies	41% ± 15%	Explore
thymus	3 studies	53% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	86%	39213.90	18 / 21	80%	324.51	404 / 504
lung	87%	41095.20	503 / 578	76%	272.44	881 / 1155
prostate	76%	21937.22	186 / 245	86%	789.01	434 / 502
intestine	70%	31328.17	674 / 966	81%	320.43	428 / 527
ovary	82%	42941.28	147 / 180	69%	277.75	296 / 430
esophagus	61%	21358.06	877 / 1445	86%	355.15	157 / 183
thymus	63%	24555.99	410 / 653	82%	710.64	497 / 605
breast	79%	33586.15	363 / 459	65%	272.06	722 / 1118
stomach	64%	35616.64	231 / 359	79%	263.13	226 / 286
skin	80%	64496.02	1451 / 1809	59%	150.32	279 / 472
pancreas	42%	11111.43	137 / 328	94%	469.46	168 / 178
kidney	61%	16699.57	54 / 89	64%	320.00	575 / 901
adrenal gland	53%	13176.88	136 / 258	64%	381.42	147 / 230
uterus	37%	17189.55	63 / 170	75%	379.94	346 / 459
brain	31%	7707.56	825 / 2642	74%	287.50	521 / 705
blood vessel	86%	53778.74	1147 / 1335	0%	0	0 / 0
adipose	83%	56147.22	1001 / 1204	0%	0	0 / 0
liver	53%	11920.19	119 / 226	21%	49.25	87 / 406
tonsil	0%	0	0 / 0	71%	424.71	32 / 45
spleen	61%	12607.46	148 / 241	0%	0	0 / 0
peripheral blood	61%	24372.84	564 / 929	0%	0	0 / 0
heart	59%	21451.25	509 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	29%	43.58	23 / 80
lymph node	0%	0	0 / 0	24%	36.65	7 / 29
muscle	16%	2877.31	132 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_1904628	Biological process	cellular response to phorbol 13-acetate 12-myristate
GO_0035994	Biological process	response to muscle stretch
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0006954	Biological process	inflammatory response
GO_0030316	Biological process	osteoclast differentiation
GO_0014856	Biological process	skeletal muscle cell proliferation
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_1990646	Biological process	cellular response to prolactin
GO_0035902	Biological process	response to immobilization stress
GO_0071456	Biological process	cellular response to hypoxia
GO_0071276	Biological process	cellular response to cadmium ion
GO_0032868	Biological process	response to insulin
GO_0071374	Biological process	cellular response to parathyroid hormone stimulus
GO_0140467	Biological process	integrated stress response signaling
GO_0014823	Biological process	response to activity
GO_0045471	Biological process	response to ethanol
GO_0007565	Biological process	female pregnancy
GO_0071277	Biological process	cellular response to calcium ion
GO_1903131	Biological process	mononuclear cell differentiation
GO_0045672	Biological process	positive regulation of osteoclast differentiation
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0060395	Biological process	SMAD protein signal transduction
GO_0051591	Biological process	response to cAMP
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0051450	Biological process	myoblast proliferation
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0001661	Biological process	conditioned taste aversion
GO_0009629	Biological process	response to gravity
GO_0009416	Biological process	response to light stimulus
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0009636	Biological process	response to toxic substance
GO_0032570	Biological process	response to progesterone
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0051412	Biological process	response to corticosterone
GO_0007399	Biological process	nervous system development
GO_0032496	Biological process	response to lipopolysaccharide
GO_0034224	Biological process	cellular response to zinc ion starvation
GO_0032993	Cellular component	protein-DNA complex
GO_0035976	Cellular component	transcription factor AP-1 complex
GO_0005654	Cellular component	nucleoplasm
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0070412	Molecular function	R-SMAD binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0001221	Molecular function	transcription coregulator binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000979	Molecular function	RNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]

Gene name	FOS
Protein name	Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) Fos proto-oncogene, AP-1 transcription factor subunit Protein c-Fos (Cellular oncogene fos)
Synonyms	hCG_22355 MBNL1 VIM G0S7 RP11-326N17.1
Description	FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. .
Accessions	G3V289 ENST00000554212.5 ENST00000555347.1 ENST00000555686.1 [P01100-2] G3V2V7 ENST00000555242.1 ENST00000303562.9 [P01100-1] G3V5N7 G3V5N9 A0A0K0TMT7 G3V5J9 ENST00000557139.1 Q6FG41 A0A0K0TMV9 H0YJM3 ENST00000554617.1 A0A0K0TMT5 ENST00000555672.1 P01100 ENST00000535987.5 [P01100-3]

FOS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review