IL1RL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL1RL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL1RL2 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0006954Biological processinflammatory response
GO_0006968Biological processcellular defense response
GO_0050727Biological processregulation of inflammatory response
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0005886Cellular componentplasma membrane
GO_0004908Molecular functioninterleukin-1 receptor activity
GO_0004909Molecular functioninterleukin-1, type I, activating receptor activity
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameIL1RL2
Protein nameInterleukin 1 receptor like 2
Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)
SynonymsIL1RRP2
DescriptionFUNCTION: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. .

AccessionsENST00000421464.1
ENST00000441515.3 [Q9HB29-2]
Q9HB29
ENST00000264257.7 [Q9HB29-1]
C9K0I8