NAIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0016045Biological processdetection of bacterium
GO_0046456Biological processicosanoid biosynthetic process
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0070269Biological processpyroptotic inflammatory response
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0042742Biological processdefense response to bacterium
GO_0006915Biological processapoptotic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0007399Biological processnervous system development
GO_0072557Cellular componentIPAF inflammasome complex
GO_0005737Cellular componentcytoplasm
GO_0061702Cellular componentcanonical inflammasome complex
GO_0016323Cellular componentbasolateral plasma membrane
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameNAIP
Protein nameBaculoviral IAP repeat-containing protein 1 (NAIP protein)
Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)
Baculoviral IAP repeat-containing protein 1 (NLR family apoptosis inhibitory protein)
Baculoviral IAP repeat-containing protein 1
NLR family apoptosis inhibitory protein
SynonymsBIRC1
DescriptionFUNCTION: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; FUNCTION: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

AccessionsA0A0G2JNC7
ENST00000610590.4
ENST00000616766.2
ENST00000503719.6 [Q13075-2]
ENST00000628482.2
ENST00000629198.2
Q13075
H0YAX2
A0A0G2JQE0
ENST00000619206.4
ENST00000620988.4
ENST00000615009.3
ENST00000508426.6
ENST00000616067.4
ENST00000622005.4
ENST00000612328.4
ENST00000519014.1
ENST00000194097.8 [Q13075-1]
A0A0G2JS53
ENST00000523981.5 [Q13075-2]
E7EQW0
B7ZLE8
ENST00000517649.6 [Q13075-1]
ENST00000514857.2
E5RJA3
ENST00000625431.2
ENST00000618877.1