IRGM report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IRGM at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IRGM at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0061762Biological processCAMKK-AMPK signaling cascade
GO_0000045Biological processautophagosome assembly
GO_0045087Biological processinnate immune response
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0060335Biological processpositive regulation of type II interferon-mediated signaling pathway
GO_0061635Biological processregulation of protein complex stability
GO_0071211Biological processprotein targeting to vacuole involved in autophagy
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0031648Biological processprotein destabilization
GO_0035458Biological processcellular response to interferon-beta
GO_0065003Biological processprotein-containing complex assembly
GO_0043032Biological processpositive regulation of macrophage activation
GO_1904417Biological processpositive regulation of xenophagy
GO_0032480Biological processnegative regulation of type I interferon production
GO_0098586Biological processcellular response to virus
GO_0050728Biological processnegative regulation of inflammatory response
GO_0010508Biological processpositive regulation of autophagy
GO_0050687Biological processnegative regulation of defense response to virus
GO_0050821Biological processprotein stabilization
GO_1905673Biological processpositive regulation of lysosome organization
GO_0042742Biological processdefense response to bacterium
GO_1901526Biological processpositive regulation of mitophagy
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032689Biological processnegative regulation of type II interferon production
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_1901098Biological processpositive regulation of autophagosome maturation
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0097352Biological processautophagosome maturation
GO_0061739Biological processprotein lipidation involved in autophagosome assembly
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0031902Cellular componentlate endosome membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0000421Cellular componentautophagosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0001891Cellular componentphagocytic cup
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0042995Cellular componentcell projection
GO_0005765Cellular componentlysosomal membrane
GO_0050700Molecular functionCARD domain binding
GO_0051434Molecular functionBH3 domain binding
GO_0019901Molecular functionprotein kinase binding
GO_0003925Molecular functionG protein activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005525Molecular functionGTP binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameIRGM
Protein nameImmunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47)
Immunity-related GTPase family, M
Immunity related GTPase M
SynonymsIRGM1
IFI1
LRG47
DescriptionFUNCTION: Immunity-related GTPase that plays important roles in innate immunity and inflammatory response . Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes . Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly . Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: IRGM (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy . Also activates autophagy by promoting recruitment of STX17 to autophagosomes . In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation . Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (By similarity). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response . Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation . Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation . Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD . Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation . .; FUNCTION: [Isoform IRGMd]: Acts as a positive regulator of mitophagy in response to intracellular mycobacteria infection: specifically binds cardiolipin, leading to its translocation to mitochondria, where it promotes affected mitochondrial fission and mitophagy. .; FUNCTION: (Microbial infection) Following infection by hepatitis C virus (HCV), promotes HCV-triggered membrane remodeling, leading to autophagy and Golgi fragmentation, a step required for HCV replication. .

AccessionsD9N2U4
ENST00000522154.2 [A1A4Y4-1]
A0A9H4B933
A1A4Y4
ENST00000520549.1