TMEM258 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006487Biological processprotein N-linked glycosylation
GO_0006954Biological processinflammatory response
GO_1904019Biological processepithelial cell apoptotic process
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0005737Cellular componentcytoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0043227Cellular componentmembrane-bounded organelle
GO_0008250Cellular componentoligosaccharyltransferase complex
GO_0034998Cellular componentoligosaccharyltransferase I complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0062062Molecular functionoligosaccharyltransferase complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM258
Protein nameTransmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)
Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258)
SynonymsHSPC005
C11orf10
DescriptionFUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity . Involved in ER homeostasis in the colonic epithelium (By similarity). .

FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. .

FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. .

AccessionsENST00000257262.12
ENST00000535297.1
F5GWH5
ENST00000545210.5
ENST00000543510.1
ENST00000537328.6
P61165
F5H7Z5
ENST00000541893.5