MGLL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0052651Biological processmonoacylglycerol catabolic process
GO_0009966Biological processregulation of signal transduction
GO_0006954Biological processinflammatory response
GO_0051930Biological processregulation of sensory perception of pain
GO_0050727Biological processregulation of inflammatory response
GO_0019433Biological processtriglyceride catabolic process
GO_0006633Biological processfatty acid biosynthetic process
GO_0046464Biological processacylglycerol catabolic process
GO_2000124Biological processregulation of endocannabinoid signaling pathway
GO_0006629Biological processlipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0004622Molecular functionlysophospholipase activity
GO_0047372Molecular functionacylglycerol lipase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMGLL
Protein nameMonoglyceride lipase
Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)
Monoacylglycerol lipase isoform 2
Synonyms
DescriptionFUNCTION: Converts monoacylglycerides to free fatty acids and glycerol . Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain . Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth . .

AccessionsENST00000496306.5
B2ZGL7
C9JAM4
ENST00000494830.1
ENST00000648300.1
H7C5K5
H7C4E0
Q99685
ENST00000398104.6 [Q99685-1]
ENST00000487473.6
ENST00000453507.7 [Q99685-2]
A0A0C4DFN3
ENST00000265052.10
A0A3B3ITT3