NOX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOX1 at tissue level.

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0001525Biological processangiogenesis
GO_0006739Biological processNADP metabolic process
GO_0045730Biological processrespiratory burst
GO_0042743Biological processhydrogen peroxide metabolic process
GO_0045726Biological processpositive regulation of integrin biosynthetic process
GO_0006954Biological processinflammatory response
GO_0042554Biological processsuperoxide anion generation
GO_0046330Biological processpositive regulation of JNK cascade
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0007165Biological processsignal transduction
GO_0003081Biological processregulation of systemic arterial blood pressure by renin-angiotensin
GO_0008217Biological processregulation of blood pressure
GO_0030198Biological processextracellular matrix organization
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0071455Biological processcellular response to hyperoxia
GO_0072592Biological processoxygen metabolic process
GO_1902177Biological processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0016477Biological processcell migration
GO_0006952Biological processdefense response
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0043020Cellular componentNADPH oxidase complex
GO_0070161Cellular componentanchoring junction
GO_0042995Cellular componentcell projection
GO_0106292Molecular functionsuperoxide-generating NADPH oxidase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0050661Molecular functionNADP binding
GO_0046872Molecular functionmetal ion binding
GO_0016175Molecular functionsuperoxide-generating NAD(P)H oxidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOX1
Protein nameNADPH oxidase 1
Nox1 NAD(P)H-oxidase subunit
NADPH oxidase 1 (NOX-1) (EC 1.6.3.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)
SynonymsMOX1
NOH1
DescriptionFUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. .; FUNCTION: [Isoform NOH-1L]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. .; FUNCTION: [Isoform NOH-1S]: Voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. .

AccessionsQ5H9D4
ENST00000372960.8
ENST00000372964.5
ENST00000372966.8 [Q9Y5S8-1]
ENST00000217885.5 [Q9Y5S8-3]
Q9Y5S8
H0Y581
A6NGA6
ENST00000427768.5
Q8TCT3