EPHA2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPHA2 at tissue level.

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0048870Biological processcell motility
GO_0048013Biological processephrin receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0072659Biological processprotein localization to plasma membrane
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0043535Biological processregulation of blood vessel endothelial cell migration
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0030316Biological processosteoclast differentiation
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0060444Biological processbranching involved in mammary gland duct morphogenesis
GO_0090630Biological processactivation of GTPase activity
GO_0001649Biological processosteoblast differentiation
GO_0007275Biological processmulticellular organism development
GO_0001570Biological processvasculogenesis
GO_0007155Biological processcell adhesion
GO_1903348Biological processpositive regulation of bicellular tight junction assembly
GO_0045765Biological processregulation of angiogenesis
GO_0046058Biological processcAMP metabolic process
GO_0002043Biological processblood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0016525Biological processnegative regulation of angiogenesis
GO_0060035Biological processnotochord cell development
GO_0033674Biological processpositive regulation of kinase activity
GO_0030182Biological processneuron differentiation
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0046718Biological processsymbiont entry into host cell
GO_1901491Biological processnegative regulation of lymphangiogenesis
GO_0046849Biological processbone remodeling
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0030335Biological processpositive regulation of cell migration
GO_0036342Biological processpost-anal tail morphogenesis
GO_0014028Biological processnotochord formation
GO_0033628Biological processregulation of cell adhesion mediated by integrin
GO_0070309Biological processlens fiber cell morphogenesis
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0032682Biological processnegative regulation of chemokine production
GO_0048320Biological processaxial mesoderm formation
GO_0001501Biological processskeletal system development
GO_1904238Biological processpericyte cell differentiation
GO_0021915Biological processneural tube development
GO_0070848Biological processresponse to growth factor
GO_0016477Biological processcell migration
GO_0060326Biological processcell chemotaxis
GO_0010591Biological processregulation of lamellipodium assembly
GO_0032587Cellular componentruffle membrane
GO_0070160Cellular componenttight junction
GO_0043235Cellular componentreceptor complex
GO_0031256Cellular componentleading edge membrane
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0031258Cellular componentlamellipodium membrane
GO_0030027Cellular componentlamellipodium
GO_0140677Molecular functionmolecular function activator activity
GO_0045296Molecular functioncadherin binding
GO_0001618Molecular functionvirus receptor activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005003Molecular functionephrin receptor activity
GO_0019838Molecular functiongrowth factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPHA2
Protein nameProtein tyrosine kinase
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
EPHA2 protein
SynonymsECK
DescriptionFUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. .; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. .; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. .

AccessionsENST00000358432.8 [P29317-1]
Q8IZL0
Q96HF4
P29317