I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| kidney distal convoluted tubule epithelial cell | 5 studies | 40% ± 8% | |
| kidney loop of Henle epithelial cell | 4 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney distal convoluted tubule epithelial cell | 5 studies | 40% ± 8% | |
| kidney loop of Henle epithelial cell | 4 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of WNK4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 95% | 1971.02 | 232 / 245 | 96% | 25.70 | 480 / 502 |
| stomach | 77% | 414.40 | 276 / 359 | 64% | 12.89 | 184 / 286 |
| intestine | 59% | 894.26 | 574 / 966 | 82% | 20.34 | 431 / 527 |
| kidney | 100% | 2776.81 | 89 / 89 | 27% | 1.94 | 243 / 901 |
| esophagus | 88% | 676.52 | 1266 / 1445 | 37% | 4.10 | 67 / 183 |
| breast | 59% | 628.19 | 272 / 459 | 65% | 18.71 | 722 / 1118 |
| skin | 46% | 255.24 | 832 / 1809 | 59% | 13.57 | 280 / 472 |
| ovary | 92% | 801.59 | 165 / 180 | 4% | 0.48 | 19 / 430 |
| eye | 0% | 0 | 0 / 0 | 59% | 4.46 | 47 / 80 |
| bladder | 19% | 29.76 | 4 / 21 | 30% | 5.21 | 150 / 504 |
| adipose | 35% | 113.85 | 419 / 1204 | 0% | 0 | 0 / 0 |
| liver | 9% | 19.31 | 20 / 226 | 24% | 2.26 | 96 / 406 |
| uterus | 9% | 14.28 | 15 / 170 | 23% | 2.13 | 104 / 459 |
| pancreas | 15% | 16.42 | 49 / 328 | 15% | 2.69 | 27 / 178 |
| lung | 9% | 11.46 | 51 / 578 | 13% | 1.24 | 150 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 1.69 | 8 / 45 |
| brain | 6% | 11.54 | 148 / 2642 | 6% | 0.41 | 41 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.22 | 1 / 29 |
| thymus | 0% | 0.18 | 1 / 653 | 1% | 0.04 | 5 / 605 |
| blood vessel | 1% | 1.01 | 12 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 4.85 | 1 / 258 | 0% | 0.17 | 1 / 230 |
| heart | 1% | 0.67 | 5 / 861 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0.29 | 1 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.22 | 2 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.19 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055074 | Biological process | calcium ion homeostasis |
| GO_0070294 | Biological process | renal sodium ion absorption |
| GO_0042116 | Biological process | macrophage activation |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0006954 | Biological process | inflammatory response |
| GO_0006821 | Biological process | chloride transport |
| GO_0007165 | Biological process | signal transduction |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0035932 | Biological process | aldosterone secretion |
| GO_0002021 | Biological process | response to dietary excess |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0070371 | Biological process | ERK1 and ERK2 cascade |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0072156 | Biological process | distal tubule morphogenesis |
| GO_0003096 | Biological process | renal sodium ion transport |
| GO_0030644 | Biological process | intracellular chloride ion homeostasis |
| GO_0010766 | Biological process | negative regulation of sodium ion transport |
| GO_0070528 | Biological process | protein kinase C signaling |
| GO_0010467 | Biological process | gene expression |
| GO_0050801 | Biological process | monoatomic ion homeostasis |
| GO_0008104 | Biological process | protein localization |
| GO_0090188 | Biological process | negative regulation of pancreatic juice secretion |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_1903077 | Biological process | negative regulation of protein localization to plasma membrane |
| GO_1903764 | Biological process | regulation of potassium ion export across plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0044297 | Cellular component | cell body |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0008200 | Molecular function | ion channel inhibitor activity |
| GO_0031404 | Molecular function | chloride ion binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WNK4 |
| Protein name | WNK lysine deficient protein kinase 4 Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) |
| Synonyms | PRKWNK4 |
| Description | FUNCTION: Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK . Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity . Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhbits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L . . |
| Accessions | ENST00000587745.1 K7ENT7 ENST00000591448.5 ENST00000246914.10 [Q96J92-1] Q96J92 K7EPB3 |
