I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 6 studies | 23% ± 7% | |
| microglial cell | 3 studies | 24% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 6 studies | 23% ± 7% | |
| microglial cell | 3 studies | 24% ± 5% |
Insufficient scRNA-seq data for expression of TLR7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 94% | 144.20 | 541 / 578 | 78% | 3.50 | 896 / 1155 |
| brain | 76% | 122.10 | 1997 / 2642 | 95% | 8.62 | 673 / 705 |
| breast | 68% | 57.89 | 312 / 459 | 95% | 7.14 | 1062 / 1118 |
| prostate | 82% | 67.31 | 200 / 245 | 60% | 1.57 | 301 / 502 |
| kidney | 53% | 39.94 | 47 / 89 | 84% | 6.97 | 761 / 901 |
| adrenal gland | 88% | 99.79 | 227 / 258 | 40% | 0.91 | 92 / 230 |
| intestine | 81% | 114.71 | 782 / 966 | 45% | 1.28 | 239 / 527 |
| bladder | 67% | 57.71 | 14 / 21 | 50% | 2.09 | 254 / 504 |
| pancreas | 37% | 23.68 | 121 / 328 | 74% | 2.59 | 131 / 178 |
| thymus | 46% | 33.59 | 300 / 653 | 64% | 2.25 | 387 / 605 |
| ovary | 34% | 17.17 | 61 / 180 | 74% | 2.97 | 318 / 430 |
| stomach | 47% | 25.91 | 168 / 359 | 61% | 2.31 | 174 / 286 |
| spleen | 100% | 338.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 9.64 | 28 / 29 |
| esophagus | 53% | 30.94 | 761 / 1445 | 42% | 1.03 | 76 / 183 |
| peripheral blood | 94% | 1346.81 | 875 / 929 | 0% | 0 | 0 / 0 |
| uterus | 41% | 24.62 | 70 / 170 | 50% | 1.40 | 229 / 459 |
| adipose | 80% | 111.01 | 963 / 1204 | 0% | 0 | 0 / 0 |
| skin | 15% | 6.78 | 266 / 1809 | 65% | 3.22 | 305 / 472 |
| blood vessel | 76% | 99.31 | 1013 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 2.84 | 31 / 45 |
| liver | 12% | 4.80 | 26 / 226 | 25% | 0.61 | 100 / 406 |
| heart | 27% | 14.61 | 230 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 24% | 0.57 | 19 / 80 |
| muscle | 7% | 2.84 | 59 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002224 | Biological process | toll-like receptor signaling pathway |
| GO_0007254 | Biological process | JNK cascade |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_0032728 | Biological process | positive regulation of interferon-beta production |
| GO_0006954 | Biological process | inflammatory response |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0034154 | Biological process | toll-like receptor 7 signaling pathway |
| GO_0045087 | Biological process | innate immune response |
| GO_0007249 | Biological process | canonical NF-kappaB signal transduction |
| GO_0051607 | Biological process | defense response to virus |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0032727 | Biological process | positive regulation of interferon-alpha production |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0007252 | Biological process | I-kappaB phosphorylation |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0060907 | Biological process | positive regulation of macrophage cytokine production |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0070305 | Biological process | response to cGMP |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0032009 | Cellular component | early phagosome |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0036020 | Cellular component | endolysosome membrane |
| GO_0038187 | Molecular function | pattern recognition receptor activity |
| GO_0003727 | Molecular function | single-stranded RNA binding |
| GO_0035197 | Molecular function | siRNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003725 | Molecular function | double-stranded RNA binding |
| Gene name | TLR7 |
| Protein name | TLR7 (Toll-like receptor 7) TLR7 Toll-like receptor 7 |
| Synonyms | hCG_1646600 UNQ248/PRO285 |
| Description | FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity . Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs . Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction . In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively . . |
| Accessions | A0A2R4P812 A0A2R4P7N7 A0A2R4P7Q4 Q9NYK1 ENST00000380659.4 D1CS68 B2R9N9 |
