POLB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0006954Biological processinflammatory response
GO_0001701Biological processin utero embryonic development
GO_0048535Biological processlymph node development
GO_0006287Biological processbase-excision repair, gap-filling
GO_0010332Biological processresponse to gamma radiation
GO_0071707Biological processimmunoglobulin heavy chain V-D-J recombination
GO_0006974Biological processDNA damage response
GO_0006290Biological processpyrimidine dimer repair
GO_0048872Biological processhomeostasis of number of cells
GO_0045471Biological processresponse to ethanol
GO_0048536Biological processspleen development
GO_0051402Biological processneuron apoptotic process
GO_0055093Biological processresponse to hyperoxia
GO_0071897Biological processDNA biosynthetic process
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0006284Biological processbase-excision repair
GO_0006297Biological processnucleotide-excision repair, DNA gap filling
GO_0007435Biological processsalivary gland morphogenesis
GO_0006261Biological processDNA-templated DNA replication
GO_0005876Cellular componentspindle microtubule
GO_0005874Cellular componentmicrotubule
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0019899Molecular functionenzyme binding
GO_0140078Molecular functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0051575Molecular function5'-deoxyribose-5-phosphate lyase activity
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0008017Molecular functionmicrotubule binding
GO_0046872Molecular functionmetal ion binding
GO_0016829Molecular functionlyase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePOLB
Protein nameDNA polymerase (EC 2.7.7.7)
DNA-directed DNA polymerase (EC 2.7.7.7)
DNA polymerase beta
DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)
Synonyms
DescriptionFUNCTION: Repair polymerase that plays a key role in base-excision repair . During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap . Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase . .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

AccessionsE5RJ55
ENST00000265421.9
P06746
H0YBJ0
E9PIC6
ENST00000519771.5
ENST00000522610.5
ENST00000521290.5
E5RHZ4
ENST00000518579.5
ENST00000521492.1
ENST00000518925.5
H0YAV8
E5RG65
ENST00000520008.5
H0YB29
E5RIJ0
ENST00000517393.1
ENST00000524208.5
H0YBX1
E7EW18
ENST00000532157.5