NKIRAS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032484Biological processRal protein signal transduction
GO_0006954Biological processinflammatory response
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0043129Biological processsurfactant homeostasis
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0048286Biological processlung alveolus development
GO_0005575Cellular componentcellular_component
GO_0005737Cellular componentcytoplasm
GO_0005525Molecular functionGTP binding
GO_0032794Molecular functionGTPase activating protein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameNKIRAS2
Protein nameNF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2)
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
NFKB inhibitor interacting Ras like 2
SynonymsKBRAS2
DescriptionFUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). .

AccessionsENST00000462043.6
ENST00000393885.9 [Q9NYR9-1]
ENST00000485789.5
ENST00000393880.5 [Q9NYR9-1]
ENST00000491638.5
H7BXP1
ENST00000587337.1
K7ER26
ENST00000393881.7 [Q9NYR9-1]
ENST00000316082.4
ENST00000585955.5
Q9NYR9
K7EKE9
A0A0A0MTA0
ENST00000479407.5 [Q9NYR9-4]
K7ELL8
ENST00000449471.8 [Q9NYR9-3]
ENST00000307641.9 [Q9NYR9-1]
K7ERG2