SMAD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0003161Biological processcardiac conduction system development
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001657Biological processureteric bud development
GO_0031053Biological processprimary miRNA processing
GO_0006954Biological processinflammatory response
GO_0002051Biological processosteoblast fate commitment
GO_0000165Biological processMAPK cascade
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_0007276Biological processgamete generation
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0030509Biological processBMP signaling pathway
GO_0060038Biological processcardiac muscle cell proliferation
GO_0006351Biological processDNA-templated transcription
GO_0060395Biological processSMAD protein signal transduction
GO_0009880Biological processembryonic pattern specification
GO_0001710Biological processmesodermal cell fate commitment
GO_0030154Biological processcell differentiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0030902Biological processhindbrain development
GO_0042592Biological processhomeostatic process
GO_0001503Biological processossification
GO_0060348Biological processbone development
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0051216Biological processcartilage development
GO_0071407Biological processcellular response to organic cyclic compound
GO_0061036Biological processpositive regulation of cartilage development
GO_0030901Biological processmidbrain development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071141Cellular componentSMAD protein complex
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005637Cellular componentnuclear inner membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071144Cellular componentheteromeric SMAD protein complex
GO_0000785Cellular componentchromatin
GO_0071142Cellular componenthomomeric SMAD protein complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0070410Molecular functionco-SMAD binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0017151Molecular functionDEAD/H-box RNA helicase binding
GO_0070411Molecular functionI-SMAD binding
GO_0070878Molecular functionprimary miRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMAD1
Protein nameMothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
SMAD family member 1
SynonymsBSP1
MADR1
MADH1
DescriptionFUNCTION: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis . Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor . In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network . SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). .

AccessionsD6REQ3
ENST00000394092.6 [Q15797-1]
ENST00000514831.1
D6RD62
ENST00000507367.1
D6RDN7
ENST00000512019.1
ENST00000503324.1
ENST00000514778.1
ENST00000302085.9 [Q15797-1]
A0A1D5RMR4
D6RBH9
Q15797
ENST00000507594.1
ENST00000515385.1 [Q15797-1]
D6RAY1