FOXP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXP3 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006954Biological processinflammatory response
GO_0014045Biological processestablishment of endothelial blood-brain barrier
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0050777Biological processnegative regulation of immune response
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0032792Biological processnegative regulation of CREB transcription factor activity
GO_0045066Biological processregulatory T cell differentiation
GO_0033092Biological processpositive regulation of immature T cell proliferation in thymus
GO_0050687Biological processnegative regulation of defense response to virus
GO_0032689Biological processnegative regulation of type II interferon production
GO_0002456Biological processT cell mediated immunity
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0033080Biological processimmature T cell proliferation in thymus
GO_0042110Biological processT cell activation
GO_0043029Biological processT cell homeostasis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032914Biological processpositive regulation of transforming growth factor beta1 production
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032831Biological processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_0048289Biological processisotype switching to IgE isotypes
GO_0002677Biological processnegative regulation of chronic inflammatory response
GO_0050852Biological processT cell receptor signaling pathway
GO_0002870Biological processT cell anergy
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0048294Biological processnegative regulation of isotype switching to IgE isotypes
GO_1901355Biological processresponse to rapamycin
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0032905Biological processtransforming growth factor beta1 production
GO_0001782Biological processB cell homeostasis
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0002513Biological processtolerance induction to self antigen
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001818Biological processnegative regulation of cytokine production
GO_0032714Biological processnegative regulation of interleukin-5 production
GO_0002669Biological processpositive regulation of T cell anergy
GO_0048302Biological processregulation of isotype switching to IgG isotypes
GO_0002667Biological processregulation of T cell anergy
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0002262Biological processmyeloid cell homeostasis
GO_0002725Biological processnegative regulation of T cell cytokine production
GO_0009615Biological processresponse to virus
GO_0002851Biological processpositive regulation of peripheral T cell tolerance induction
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0032713Biological processnegative regulation of interleukin-4 production
GO_0002362Biological processCD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005829Cellular componentcytosol
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0051525Molecular functionNFAT protein binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0046872Molecular functionmetal ion binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameFOXP3
Protein nameFOXP3 protein (Forkhead box P3)
Forkhead box P3
Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
SynonymsJM2
IPEX
DescriptionFUNCTION: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) . Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells . Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases . The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) . Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 . Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 . Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 . Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development . Inhibits the transcriptional activator activity of RORA . Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). .

AccessionsB7ZLG1
ENST00000455775.7
ENST00000376199.7 [Q9BZS1-2]
A0A804HK12
A0A494BZV0
Q9BZS1
ENST00000557224.6 [Q9BZS1-3]
ENST00000684155.1
ENST00000376207.10 [Q9BZS1-1]
ENST00000652559.1
A0A494C0B0
ENST00000651307.1
ENST00000518685.6 [Q9BZS1-4]