CSRP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007519Biological processskeletal muscle tissue development
GO_0006954Biological processinflammatory response
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0002026Biological processregulation of the force of heart contraction
GO_0003300Biological processcardiac muscle hypertrophy
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0033365Biological processprotein localization to organelle
GO_0060048Biological processcardiac muscle contraction
GO_0055003Biological processcardiac myofibril assembly
GO_0060537Biological processmuscle tissue development
GO_0008286Biological processinsulin receptor signaling pathway
GO_0033292Biological processT-tubule organization
GO_0035995Biological processdetection of muscle stretch
GO_0048738Biological processcardiac muscle tissue development
GO_0045214Biological processsarcomere organization
GO_0070528Biological processprotein kinase C signaling
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005856Cellular componentcytoskeleton
GO_0030018Cellular componentZ disc
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008307Molecular functionstructural constituent of muscle
GO_0042802Molecular functionidentical protein binding
GO_0031433Molecular functiontelethonin binding
GO_0046872Molecular functionmetal ion binding
GO_0042805Molecular functionactinin binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameCSRP3
Protein nameCysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (cDNA, FLJ93801, Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIMprotein) (CSRP3), mRNA)
Cysteine and glycine rich protein 3
SynonymsMLP
hCG_1811041
CLP
DescriptionFUNCTION: Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization . Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association . In vitro can inhibit PKC/PRKCA activity . Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). .; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. .

AccessionsA0A3B3IRI5
ENST00000533783.2 [P50461-1]
ENST00000647990.1
P50461
A0A3B3ISZ2
A0A7R6RQ65
A0A7R6RR27
A0A3B3IT61
ENST00000649842.1
ENST00000649235.1 [P50461-1]
A2TDB8
ENST00000265968.9 [P50461-1]
ENST00000648719.1