PARK7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0036530Biological processprotein deglycation, methylglyoxal removal
GO_0006281Biological processDNA repair
GO_0006954Biological processinflammatory response
GO_1903377Biological processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0046295Biological processglycolate biosynthetic process
GO_2000157Biological processnegative regulation of ubiquitin-specific protease activity
GO_0106045Biological processguanine deglycation, methylglyoxal removal
GO_1903197Biological processpositive regulation of L-dopa biosynthetic process
GO_0036529Biological processprotein deglycation, glyoxal removal
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_1903751Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0050821Biological processprotein stabilization
GO_0106044Biological processguanine deglycation
GO_0110095Biological processcellular detoxification of aldehyde
GO_0030073Biological processinsulin secretion
GO_1903384Biological processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006914Biological processautophagy
GO_0032091Biological processnegative regulation of protein binding
GO_0006979Biological processresponse to oxidative stress
GO_0070301Biological processcellular response to hydrogen peroxide
GO_1903122Biological processnegative regulation of TRAIL-activated apoptotic signaling pathway
GO_0042743Biological processhydrogen peroxide metabolic process
GO_1903376Biological processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0098869Biological processcellular oxidant detoxification
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0010628Biological processpositive regulation of gene expression
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0002866Biological processpositive regulation of acute inflammatory response to antigenic stimulus
GO_0050727Biological processregulation of inflammatory response
GO_0043523Biological processregulation of neuron apoptotic process
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0070994Biological processdetection of oxidative stress
GO_0060081Biological processmembrane hyperpolarization
GO_1903178Biological processpositive regulation of tyrosine 3-monooxygenase activity
GO_0050787Biological processdetoxification of mercury ion
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0006517Biological processprotein deglycosylation
GO_1903200Biological processpositive regulation of L-dopa decarboxylase activity
GO_1902958Biological processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
GO_1903189Biological processglyoxal metabolic process
GO_0009438Biological processmethylglyoxal metabolic process
GO_1905259Biological processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO_0007265Biological processRas protein signal transduction
GO_0046826Biological processnegative regulation of protein export from nucleus
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0051899Biological processmembrane depolarization
GO_0032148Biological processactivation of protein kinase B activity
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_1902903Biological processregulation of supramolecular fiber organization
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_1903073Biological processnegative regulation of death-inducing signaling complex assembly
GO_0036526Biological processpeptidyl-cysteine deglycation
GO_0061691Biological processdetoxification of hydrogen peroxide
GO_0034599Biological processcellular response to oxidative stress
GO_0007005Biological processmitochondrion organization
GO_0033864Biological processpositive regulation of NAD(P)H oxidase activity
GO_0061727Biological processmethylglyoxal catabolic process to lactate
GO_0006508Biological processproteolysis
GO_0036471Biological processcellular response to glyoxal
GO_1902177Biological processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0036527Biological processpeptidyl-arginine deglycation
GO_0007338Biological processsingle fertilization
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_1903599Biological processpositive regulation of autophagy of mitochondrion
GO_2001268Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0106046Biological processguanine deglycation, glyoxal removal
GO_0008344Biological processadult locomotory behavior
GO_0051583Biological processdopamine uptake involved in synaptic transmission
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_1903181Biological processpositive regulation of dopamine biosynthetic process
GO_0140041Biological processcellular detoxification of methylglyoxal
GO_0010273Biological processdetoxification of copper ion
GO_0036528Biological processpeptidyl-lysine deglycation
GO_0033234Biological processnegative regulation of protein sumoylation
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_1903168Biological processpositive regulation of pyrroline-5-carboxylate reductase activity
GO_1903190Biological processglyoxal catabolic process
GO_2000825Biological processpositive regulation of androgen receptor activity
GO_1901671Biological processpositive regulation of superoxide dismutase activity
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0019249Biological processlactate biosynthetic process
GO_0032679Biological processregulation of TRAIL production
GO_1903094Biological processnegative regulation of protein K48-linked deubiquitination
GO_1901984Biological processnegative regulation of protein acetylation
GO_0042593Biological processglucose homeostasis
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0098793Cellular componentpresynapse
GO_0045121Cellular componentmembrane raft
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005912Cellular componentadherens junction
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0000785Cellular componentchromatin
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0044297Cellular componentcell body
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_1990422Molecular functionglyoxalase (glycolic acid-forming) activity
GO_0019955Molecular functioncytokine binding
GO_0042802Molecular functionidentical protein binding
GO_0097110Molecular functionscaffold protein binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_1903135Molecular functioncupric ion binding
GO_0044388Molecular functionsmall protein activating enzyme binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0019900Molecular functionkinase binding
GO_0019826Molecular functionoxygen sensor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0016532Molecular functionsuperoxide dismutase copper chaperone activity
GO_0051920Molecular functionperoxiredoxin activity
GO_0016684Molecular functionoxidoreductase activity, acting on peroxide as acceptor
GO_0036524Molecular functionprotein deglycase activity
GO_0019899Molecular functionenzyme binding
GO_0008233Molecular functionpeptidase activity
GO_0045340Molecular functionmercury ion binding
GO_0003729Molecular functionmRNA binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0044390Molecular functionubiquitin-like protein conjugating enzyme binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0036470Molecular functiontyrosine 3-monooxygenase activator activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0045296Molecular functioncadherin binding
GO_0036478Molecular functionL-dopa decarboxylase activator activity
GO_1903136Molecular functioncuprous ion binding
GO_0003713Molecular functiontranscription coactivator activity

IV. Literature review

[source]
Gene namePARK7
Protein nameParkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)
protein deglycase (EC 3.5.1.124) (Maillard deglycase) (Parkinsonism-associated deglycase) (Protein DJ-1) (Protein/nucleic acid deglycase DJ-1)
Parkinsonism associated deglycase
Synonyms
DescriptionFUNCTION: Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease . It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway . Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals . But this function is rebuted by other works . As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage . Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair . Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin . Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels . Displays a very low glyoxalase activity that may reflect its deglycase activity . Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death . Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria . Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking . Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells . In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress . Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity . In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). .

AccessionsENST00000338639.10
ENST00000493373.5
K7EN27
Q99497
ENST00000377488.5
K7ELW0
ENST00000377491.5
ENST00000493678.5
ENST00000469225.1
ENST00000377493.9