CCL14 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCL14 at tissue level.

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0006954Biological processinflammatory response
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0048245Biological processeosinophil chemotaxis
GO_0005615Cellular componentextracellular space
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0008009Molecular functionchemokine activity

IV. Literature review

[source]
Gene nameCCL14
Protein nameC-C motif chemokine 14 (C-C motif chemokine ligand 14)
C-C motif chemokine
C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]
SynonymsNCC2
SCYA14
DescriptionFUNCTION: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. .

AccessionsENST00000632700.1 [Q16627-1]
ENST00000619040.4 [Q16627-2]
Q16627
A0A087X089
ENST00000614009.1
ENST00000618060.2
ENST00000622526.1 [Q16627-2]
ENST00000618404.5 [Q16627-1]
A0A0B4J2G5
ENST00000620991.1