H2BC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2BC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2BC1 at tissue level.

III. Associated gene sets

GO_0071674Biological processmononuclear cell migration
GO_0035092Biological processsperm DNA condensation
GO_0006337Biological processnucleosome disassembly
GO_0006954Biological processinflammatory response
GO_0051276Biological processchromosome organization
GO_0031639Biological processplasminogen activation
GO_0006334Biological processnucleosome assembly
GO_0009986Cellular componentcell surface
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0001674Cellular componentfemale germ cell nucleus
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameH2BC1
Protein nameHistone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
SynonymsHIST1H2BA
TSH2B
DescriptionFUNCTION: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear . .

AccessionsQ96A08
ENST00000274764.5