Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 9 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1282.33 | 577 / 578 | 87% | 5.75 | 1004 / 1155 |
| intestine | 98% | 482.88 | 944 / 966 | 59% | 2.72 | 313 / 527 |
| breast | 91% | 286.56 | 418 / 459 | 63% | 3.75 | 706 / 1118 |
| brain | 65% | 134.53 | 1710 / 2642 | 89% | 8.86 | 627 / 705 |
| uterus | 82% | 197.76 | 139 / 170 | 72% | 4.71 | 329 / 459 |
| bladder | 90% | 418.14 | 19 / 21 | 61% | 3.71 | 307 / 504 |
| stomach | 86% | 240.62 | 310 / 359 | 64% | 2.71 | 182 / 286 |
| thymus | 92% | 368.35 | 602 / 653 | 51% | 5.07 | 307 / 605 |
| kidney | 75% | 293.62 | 67 / 89 | 67% | 4.13 | 603 / 901 |
| esophagus | 82% | 225.69 | 1178 / 1445 | 55% | 2.17 | 100 / 183 |
| prostate | 92% | 346.46 | 225 / 245 | 39% | 1.50 | 196 / 502 |
| adrenal gland | 94% | 307.25 | 243 / 258 | 37% | 2.54 | 84 / 230 |
| skin | 54% | 119.24 | 977 / 1809 | 65% | 5.74 | 305 / 472 |
| liver | 80% | 192.95 | 181 / 226 | 33% | 1.72 | 133 / 406 |
| pancreas | 26% | 52.48 | 84 / 328 | 79% | 5.06 | 141 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 34.18 | 29 / 29 |
| peripheral blood | 100% | 8547.67 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4453.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 589.58 | 1191 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 7.78 | 43 / 45 |
| ovary | 44% | 97.82 | 80 / 180 | 51% | 2.16 | 219 / 430 |
| blood vessel | 84% | 498.51 | 1115 / 1335 | 0% | 0 | 0 / 0 |
| heart | 65% | 155.98 | 561 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 33% | 1.69 | 26 / 80 |
| muscle | 13% | 21.94 | 108 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0030041 | Biological process | actin filament polymerization |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007155 | Biological process | cell adhesion |
| GO_0006897 | Biological process | endocytosis |
| GO_0045087 | Biological process | innate immune response |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0005829 | Cellular component | cytosol |
| GO_0001931 | Cellular component | uropod |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005884 | Cellular component | actin filament |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042802 | Molecular function | identical protein binding |
| Gene name | PSTPIP1 |
| Protein name | Proline-serine-threonine phosphatase interacting protein 1 Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) Proline-serine-threonine phosphatase interacting protein 1 isoform 1 Truncated proline-serine-threonine phosphatase interacting protein 1 Proline-serine-threonine phosphatase interacting protein 1 isoform 3 Proline-serine-threonine phosphatase interacting protein 1 (cDNA FLJ60215, highly similar to Proline-serine-threoninephosphatase-interacting protein 1) |
| Synonyms | CD2BP1 |
| Description | FUNCTION: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. . |
| Accessions | ENST00000379595.7 J3KPG6 A0A0S2Z5P3 O43586 A0A0U4DJ03 H0YLX8 ENST00000559785.5 ENST00000559856.1 H0YLI2 A0A0U4FJP1 A0A0U4DR30 H0YLW8 ENST00000559161.5 A0A0U4D6H6 A0A0U4EZ27 A0A0U3N0W4 A0A0U4ERE8 A0A023JC58 ENST00000560223.5 ENST00000559750.5 ENST00000558407.5 B4E1Z9 A0A0U4EBU9 H0YKY3 H0YKF1 H0YNR2 ENST00000558870.1 ENST00000559295.5 [O43586-2] ENST00000559859.5 ENST00000560796.5 H0YLM9 H0YNS1 ENST00000558012.6 [O43586-1] A0A0S2Z528 |
