PTGER4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0007254Biological processJNK cascade
GO_2000420Biological processnegative regulation of eosinophil extravasation
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0071260Biological processcellular response to mechanical stimulus
GO_0009624Biological processresponse to nematode
GO_0042093Biological processT-helper cell differentiation
GO_0006955Biological processimmune response
GO_0070371Biological processERK1 and ERK2 cascade
GO_0050728Biological processnegative regulation of inflammatory response
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0051492Biological processregulation of stress fiber assembly
GO_0033624Biological processnegative regulation of integrin activation
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0001818Biological processnegative regulation of cytokine production
GO_0009612Biological processresponse to mechanical stimulus
GO_0050729Biological processpositive regulation of inflammatory response
GO_0001819Biological processpositive regulation of cytokine production
GO_0060348Biological processbone development
GO_0030278Biological processregulation of ossification
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004957Molecular functionprostaglandin E receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTGER4
Protein nameProstaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor)
SynonymsPTGER2
DescriptionFUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. .

AccessionsENST00000302472.4
A0PJF5
P35408