LIAS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009107Biological processlipoate biosynthetic process
GO_0006954Biological processinflammatory response
GO_0006979Biological processresponse to oxidative stress
GO_0001843Biological processneural tube closure
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0016992Molecular functionlipoate synthase activity
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameLIAS
Protein nameLipoic acid synthetase
lipoyl synthase (EC 2.8.1.8)
LIAS protein (Lipoic acid synthetase) (cDNA FLJ76626)
Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)
SynonymsLAS
HUSSY-01
DescriptionFUNCTION: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. .

FUNCTION: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. .

AccessionsA0A1X7SBR7
ENST00000513731.6
A0A1W2PQ87
Q6P5Q6
ENST00000639422.1
ENST00000638816.1
D6RCP8
A0A1W2PQS9
A0A1W2PRD2
ENST00000638430.1
A0A1W2PPM2
ENST00000424936.6
ENST00000509519.5
ENST00000640672.1
A0A1W2PQ02
ENST00000638451.1
ENST00000340169.7 [O43766-2]
ENST00000640888.2 [O43766-1]
A0A1W2PR81
ENST00000640689.1
ENST00000381846.2 [O43766-3]
B4E0L7
ENST00000640489.1
A0A1W2PRE7
ENST00000261434.8
A0A1W2PR40
ENST00000640349.1
A0A1W2PNQ5
A0A1W2PQE9
O43766
ENST00000638837.1
ENST00000638422.1