CHUK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0043200Biological processresponse to amino acid
GO_0006954Biological processinflammatory response
GO_0034614Biological processcellular response to reactive oxygen species
GO_0010034Biological processresponse to acetate
GO_0003009Biological processskeletal muscle contraction
GO_0061847Biological processresponse to cholecystokinin
GO_0045087Biological processinnate immune response
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0009615Biological processresponse to virus
GO_0071276Biological processcellular response to cadmium ion
GO_0033194Biological processresponse to hydroperoxide
GO_0051146Biological processstriated muscle cell differentiation
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_0098586Biological processcellular response to virus
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0007252Biological processI-kappaB phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0009653Biological processanatomical structure morphogenesis
GO_0007266Biological processRho protein signal transduction
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0035631Cellular componentCD40 receptor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008385Cellular componentIkappaB kinase complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0008384Molecular functionIkappaB kinase activity
GO_1990459Molecular functiontransferrin receptor binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0097110Molecular functionscaffold protein binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHUK
Protein nameInhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC 2.7.11.10) (Nuclear factor NF-kappa-B inhibitor kinase alpha)
SynonymsTCF16
IKKA
DescriptionFUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses . Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues . These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome . In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis . Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) . Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes . In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities . Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP . Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor . Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity . .

AccessionsQ562E6
O15111
ENST00000370397.8