SMPDL3B | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	24% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMPDL3B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	1083.85	328 / 328	86%	12.49	153 / 178
thymus	100%	794.97	653 / 653	84%	29.47	510 / 605
prostate	80%	151.53	196 / 245	95%	21.91	477 / 502
lung	88%	372.35	511 / 578	78%	27.84	900 / 1155
stomach	76%	593.44	272 / 359	90%	19.74	256 / 286
kidney	98%	255.11	87 / 89	51%	7.76	459 / 901
intestine	52%	505.00	503 / 966	94%	22.05	496 / 527
breast	58%	163.52	267 / 459	87%	15.22	976 / 1118
ovary	3%	2.64	6 / 180	99%	38.75	424 / 430
bladder	29%	39.52	6 / 21	59%	13.70	299 / 504
spleen	83%	107.27	200 / 241	0%	0	0 / 0
uterus	8%	12.66	14 / 170	69%	15.17	316 / 459
esophagus	20%	19.31	296 / 1445	52%	9.59	96 / 183
tonsil	0%	0	0 / 0	64%	8.85	29 / 45
peripheral blood	45%	48.13	416 / 929	0%	0	0 / 0
skin	30%	30.85	550 / 1809	8%	0.88	36 / 472
adipose	28%	44.56	339 / 1204	0%	0	0 / 0
brain	23%	42.50	600 / 2642	1%	0.04	4 / 705
liver	4%	3.92	10 / 226	9%	0.89	36 / 406
heart	4%	3.86	33 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.39	1 / 29
eye	0%	0	0 / 0	3%	0.17	2 / 80
blood vessel	2%	2.45	33 / 1335	0%	0	0 / 0
adrenal gland	0%	0.66	1 / 258	0%	0.10	1 / 230
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006685	Biological process	sphingomyelin catabolic process
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0006954	Biological process	inflammatory response
GO_0034122	Biological process	negative regulation of toll-like receptor signaling pathway
GO_0008150	Biological process	biological_process
GO_0045087	Biological process	innate immune response
GO_0046466	Biological process	membrane lipid catabolic process
GO_0005615	Cellular component	extracellular space
GO_0098552	Cellular component	side of membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0004767	Molecular function	sphingomyelin phosphodiesterase activity
GO_0016798	Molecular function	hydrolase activity, acting on glycosyl bonds
GO_0008270	Molecular function	zinc ion binding
GO_0008081	Molecular function	phosphoric diester hydrolase activity

Gene name	SMPDL3B
Protein name	Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) Sphingomyelin phosphodiesterase acid like 3B
Synonyms	ASMLPD ASML3B
Description	FUNCTION: Lipid-modulating phosphodiesterase . Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). .
Accessions	F8VXS3 ENST00000411604.5 Q92485 F8VWW8 Q5T0Y8 ENST00000373888.8 [Q92485-2] ENST00000373894.8 [Q92485-1] ENST00000549094.1 ENST00000548116.5

SMPDL3B report