Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 26% ± 11% | |
microglial cell | 10 studies | 27% ± 10% | |
glutamatergic neuron | 9 studies | 40% ± 25% | |
adipocyte | 9 studies | 28% ± 7% | |
astrocyte | 9 studies | 29% ± 13% | |
macrophage | 8 studies | 28% ± 11% | |
oligodendrocyte | 8 studies | 28% ± 9% | |
ciliated cell | 7 studies | 21% ± 4% | |
B cell | 7 studies | 23% ± 6% | |
myeloid cell | 7 studies | 22% ± 4% | |
fibroblast | 7 studies | 24% ± 9% | |
GABAergic neuron | 7 studies | 41% ± 22% | |
plasmacytoid dendritic cell | 7 studies | 23% ± 9% | |
type I pneumocyte | 6 studies | 26% ± 7% | |
epithelial cell | 5 studies | 39% ± 13% | |
endothelial cell of lymphatic vessel | 5 studies | 21% ± 4% | |
club cell | 5 studies | 23% ± 6% | |
type II pneumocyte | 5 studies | 26% ± 6% | |
cardiac muscle cell | 4 studies | 25% ± 2% | |
oligodendrocyte precursor cell | 4 studies | 32% ± 9% | |
dendritic cell | 4 studies | 23% ± 3% | |
monocyte | 4 studies | 22% ± 4% | |
smooth muscle cell | 4 studies | 19% ± 2% | |
basal cell | 4 studies | 30% ± 18% | |
interneuron | 4 studies | 47% ± 22% | |
GABAergic interneuron | 3 studies | 20% ± 2% | |
plasma cell | 3 studies | 36% ± 9% | |
amacrine cell | 3 studies | 19% ± 3% | |
respiratory goblet cell | 3 studies | 20% ± 2% | |
hepatocyte | 3 studies | 54% ± 21% | |
T cell | 3 studies | 20% ± 4% | |
alveolar macrophage | 3 studies | 24% ± 6% | |
pericyte | 3 studies | 25% ± 10% | |
lymphocyte | 3 studies | 24% ± 5% | |
goblet cell | 3 studies | 44% ± 22% | |
abnormal cell | 3 studies | 27% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 3730.00 | 21 / 21 | 100% | 20.56 | 504 / 504 |
breast | 100% | 3783.69 | 459 / 459 | 100% | 32.83 | 1118 / 1118 |
esophagus | 100% | 3502.56 | 1445 / 1445 | 100% | 26.66 | 183 / 183 |
intestine | 100% | 3712.95 | 966 / 966 | 100% | 24.45 | 527 / 527 |
ovary | 100% | 3555.69 | 180 / 180 | 100% | 21.46 | 430 / 430 |
prostate | 100% | 3582.12 | 245 / 245 | 100% | 26.87 | 502 / 502 |
stomach | 100% | 2676.08 | 359 / 359 | 100% | 24.08 | 286 / 286 |
thymus | 100% | 4101.26 | 653 / 653 | 100% | 29.77 | 605 / 605 |
uterus | 100% | 3492.68 | 170 / 170 | 100% | 24.51 | 459 / 459 |
lung | 100% | 3604.11 | 577 / 578 | 100% | 25.92 | 1155 / 1155 |
kidney | 100% | 2450.17 | 89 / 89 | 100% | 22.28 | 899 / 901 |
liver | 100% | 2854.82 | 226 / 226 | 100% | 17.03 | 405 / 406 |
pancreas | 100% | 2072.95 | 327 / 328 | 100% | 20.00 | 178 / 178 |
brain | 100% | 2679.17 | 2632 / 2642 | 100% | 23.79 | 705 / 705 |
skin | 100% | 4805.11 | 1809 / 1809 | 99% | 22.67 | 468 / 472 |
adrenal gland | 100% | 3532.00 | 258 / 258 | 97% | 15.69 | 224 / 230 |
adipose | 100% | 3464.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3504.18 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 20.92 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 31.11 | 29 / 29 |
muscle | 100% | 4712.40 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3608.91 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.38 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.08 | 1 / 1 |
heart | 97% | 2291.97 | 831 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 83% | 2236.10 | 775 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006366 | Biological process | transcription by RNA polymerase II |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006954 | Biological process | inflammatory response |
GO_0045347 | Biological process | negative regulation of MHC class II biosynthetic process |
GO_0051865 | Biological process | protein autoubiquitination |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0005730 | Cellular component | nucleolus |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0008270 | Molecular function | zinc ion binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NFX1 |
Protein name | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) NFX1 protein Alternative protein NFX1 |
Synonyms | NFX2 |
Description | FUNCTION: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. . |
Accessions | ENST00000379540.8 [Q12986-1] ENST00000318524.6 [Q12986-3] L8ECM9 A0JLR2 Q12986 |