NFX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0016567Biological processprotein ubiquitination
GO_0006954Biological processinflammatory response
GO_0045347Biological processnegative regulation of MHC class II biosynthetic process
GO_0051865Biological processprotein autoubiquitination
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFX1
Protein nameTranscriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)
NFX1 protein
Alternative protein NFX1
SynonymsNFX2
DescriptionFUNCTION: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. .

AccessionsENST00000379540.8 [Q12986-1]
ENST00000318524.6 [Q12986-3]
L8ECM9
A0JLR2
Q12986