CSF1R report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CSF1R at tissue level.

III. Associated gene sets

GO_0120041Biological processpositive regulation of macrophage proliferation
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0061098Biological processpositive regulation of protein tyrosine kinase activity
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0032722Biological processpositive regulation of chemokine production
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006954Biological processinflammatory response
GO_0008283Biological processcell population proliferation
GO_0030097Biological processhemopoiesis
GO_0002931Biological processresponse to ischemia
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0031529Biological processruffle organization
GO_0061518Biological processmicroglial cell proliferation
GO_0030316Biological processosteoclast differentiation
GO_0030225Biological processmacrophage differentiation
GO_0045087Biological processinnate immune response
GO_0021879Biological processforebrain neuron differentiation
GO_0007165Biological processsignal transduction
GO_0045124Biological processregulation of bone resorption
GO_0007275Biological processmulticellular organism development
GO_0038145Biological processmacrophage colony-stimulating factor signaling pathway
GO_2000147Biological processpositive regulation of cell motility
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0060603Biological processmammary gland duct morphogenesis
GO_0044794Biological processpositive regulation by host of viral process
GO_0021772Biological processolfactory bulb development
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0033674Biological processpositive regulation of kinase activity
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0036006Biological processcellular response to macrophage colony-stimulating factor stimulus
GO_0071345Biological processcellular response to cytokine stimulus
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_1905521Biological processregulation of macrophage migration
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0008360Biological processregulation of cell shape
GO_0043408Biological processregulation of MAPK cascade
GO_0046777Biological processprotein autophosphorylation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0030224Biological processmonocyte differentiation
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0045217Biological processcell-cell junction maintenance
GO_0007411Biological processaxon guidance
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_1990682Cellular componentCSF1-CSF1R complex
GO_0005654Cellular componentnucleoplasm
GO_0009986Cellular componentcell surface
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042803Molecular functionprotein homodimerization activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019955Molecular functioncytokine binding
GO_0005011Molecular functionmacrophage colony-stimulating factor receptor activity
GO_0019838Molecular functiongrowth factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCSF1R
Protein namePlatelet-derived growth factor receptor-like protein
receptor protein-tyrosine kinase (EC 2.7.10.1)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Colony stimulating factor 1 receptor
Colony stimulating factor receptor
SynonymsFMS
DescriptionFUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway . Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages . .

AccessionsH0YAL5
A2VDG3
ENST00000511344.1
Q14085
ENST00000543093.1 [P07333-2]
ENST00000286301.7 [P07333-1]
D6RGW1
E9PEK4
ENST00000675795.1 [P07333-1]
ENST00000504875.5
ENST00000515068.1
P07333