STK39 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0070294Biological processrenal sodium ion absorption
GO_0042116Biological processmacrophage activation
GO_0035865Biological processcellular response to potassium ion
GO_0038146Biological processchemokine (C-X-C motif) ligand 12 signaling pathway
GO_0071476Biological processcellular hypotonic response
GO_0006954Biological processinflammatory response
GO_1901380Biological processnegative regulation of potassium ion transmembrane transport
GO_1905408Biological processnegative regulation of creatine transmembrane transporter activity
GO_0007165Biological processsignal transduction
GO_0008217Biological processregulation of blood pressure
GO_0010820Biological processpositive regulation of T cell chemotaxis
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0006884Biological processcell volume homeostasis
GO_0050727Biological processregulation of inflammatory response
GO_0002021Biological processresponse to dietary excess
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0035556Biological processintracellular signal transduction
GO_0036438Biological processmaintenance of lens transparency
GO_1904044Biological processresponse to aldosterone
GO_0030644Biological processintracellular chloride ion homeostasis
GO_0032414Biological processpositive regulation of ion transmembrane transporter activity
GO_0043268Biological processpositive regulation of potassium ion transport
GO_1990869Biological processcellular response to chemokine
GO_1901017Biological processnegative regulation of potassium ion transmembrane transporter activity
GO_0071474Biological processcellular hyperosmotic response
GO_0090188Biological processnegative regulation of pancreatic juice secretion
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_0035725Biological processsodium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0044297Cellular componentcell body
GO_0016323Cellular componentbasolateral plasma membrane
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTK39
Protein nameSTE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine threonine kinase 39 isoform C
SynonymsSPAK
PASK
DescriptionFUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure . Specifically recognizes and binds proteins with a RFXV motif . Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity . Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases . Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux . Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 . Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). .

AccessionsX5D9L8
X5DP03
X5D2U3
X5D7P8
X5D2Y0
Q9UEW8
ENST00000355999.5 [Q9UEW8-1]
A0A8V8TKT5
ENST00000697205.1