CCL3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	43% ± 21%	Explore
macrophage	31 studies	49% ± 18%	Explore
classical monocyte	18 studies	37% ± 21%	Explore
monocyte	15 studies	42% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 15%	Explore
conventional dendritic cell	14 studies	36% ± 13%	Explore
mature NK T cell	13 studies	29% ± 11%	Explore
non-classical monocyte	11 studies	37% ± 19%	Explore
CD8-positive, alpha-beta T cell	10 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	47% ± 20%	Explore
myeloid cell	7 studies	56% ± 18%	Explore
dendritic cell	6 studies	36% ± 12%	Explore
neutrophil	6 studies	52% ± 25%	Explore
leukocyte	6 studies	32% ± 6%	Explore
gamma-delta T cell	6 studies	24% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	33% ± 13%	Explore
microglial cell	4 studies	49% ± 34%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	25% ± 11%	Explore
T cell	3 studies	28% ± 8%	Explore
mononuclear phagocyte	3 studies	34% ± 12%	Explore
innate lymphoid cell	3 studies	23% ± 8%	Explore
inflammatory macrophage	3 studies	55% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	27% ± 12%	Explore
lung	3 studies	33% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	356.43	571 / 578	77%	2.87	895 / 1155
breast	68%	63.69	314 / 459	72%	2.46	804 / 1118
liver	84%	79.89	190 / 226	46%	1.15	186 / 406
kidney	57%	29.87	51 / 89	66%	2.61	592 / 901
intestine	47%	25.00	454 / 966	69%	3.30	364 / 527
adrenal gland	62%	53.59	159 / 258	54%	2.87	125 / 230
brain	28%	27.12	745 / 2642	85%	11.79	600 / 705
bladder	48%	27.95	10 / 21	59%	3.14	296 / 504
stomach	38%	22.11	138 / 359	65%	2.92	187 / 286
thymus	44%	22.31	287 / 653	59%	1.68	359 / 605
lymph node	0%	0	0 / 0	100%	19.52	29 / 29
spleen	100%	623.92	241 / 241	0%	0	0 / 0
ovary	26%	9.81	46 / 180	68%	2.23	292 / 430
uterus	28%	11.28	47 / 170	66%	2.44	301 / 459
skin	13%	4.45	229 / 1809	72%	3.35	342 / 472
peripheral blood	84%	2015.04	780 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	3.46	37 / 45
adipose	80%	114.10	967 / 1204	0%	0	0 / 0
prostate	40%	21.34	98 / 245	40%	0.92	200 / 502
pancreas	13%	4.65	41 / 328	58%	1.63	104 / 178
esophagus	13%	4.68	190 / 1445	46%	1.30	84 / 183
blood vessel	54%	67.14	720 / 1335	0%	0	0 / 0
heart	36%	17.09	308 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	20%	0.52	16 / 80
muscle	5%	2.06	40 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043615	Biological process	astrocyte cell migration
GO_0070723	Biological process	response to cholesterol
GO_1903980	Biological process	positive regulation of microglial cell activation
GO_1904141	Biological process	positive regulation of microglial cell migration
GO_0006954	Biological process	inflammatory response
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0019722	Biological process	calcium-mediated signaling
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0000165	Biological process	MAPK cascade
GO_0010629	Biological process	negative regulation of gene expression
GO_0050918	Biological process	positive chemotaxis
GO_0001649	Biological process	osteoblast differentiation
GO_0043308	Biological process	eosinophil degranulation
GO_0043922	Biological process	negative regulation by host of viral transcription
GO_0010628	Biological process	positive regulation of gene expression
GO_0030593	Biological process	neutrophil chemotaxis
GO_0050795	Biological process	regulation of behavior
GO_0051930	Biological process	regulation of sensory perception of pain
GO_0071347	Biological process	cellular response to interleukin-1
GO_0006935	Biological process	chemotaxis
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0007010	Biological process	cytoskeleton organization
GO_0007267	Biological process	cell-cell signaling
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0090280	Biological process	positive regulation of calcium ion import
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0001775	Biological process	cell activation
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0006887	Biological process	exocytosis
GO_0030335	Biological process	positive regulation of cell migration
GO_0048247	Biological process	lymphocyte chemotaxis
GO_0030502	Biological process	negative regulation of bone mineralization
GO_2000503	Biological process	positive regulation of natural killer cell chemotaxis
GO_0048245	Biological process	eosinophil chemotaxis
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0008360	Biological process	regulation of cell shape
GO_0071621	Biological process	granulocyte chemotaxis
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0009636	Biological process	response to toxic substance
GO_0002548	Biological process	monocyte chemotaxis
GO_0010818	Biological process	T cell chemotaxis
GO_0014808	Biological process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0006816	Biological process	calcium ion transport
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0023052	Biological process	signaling
GO_0048246	Biological process	macrophage chemotaxis
GO_0071346	Biological process	cellular response to type II interferon
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0016004	Molecular function	phospholipase activator activity
GO_0031726	Molecular function	CCR1 chemokine receptor binding
GO_0031730	Molecular function	CCR5 chemokine receptor binding
GO_0008009	Molecular function	chemokine activity
GO_0048020	Molecular function	CCR chemokine receptor binding
GO_0042802	Molecular function	identical protein binding
GO_0004672	Molecular function	protein kinase activity
GO_0042056	Molecular function	chemoattractant activity
GO_0016301	Molecular function	kinase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CCL3
Protein name	C-C motif chemokine C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Synonyms	SCYA3 G0S19-1 MIP1A hCG_1749202
Description	FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). .
Accessions	P10147 ENST00000616221.2 A0N0R1 ENST00000613396.2 ENST00000613922.2

CCL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review