ADAM8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	25 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	33% ± 10%	Explore
conventional dendritic cell	11 studies	27% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 6%	Explore
dendritic cell	10 studies	30% ± 13%	Explore
classical monocyte	8 studies	24% ± 9%	Explore
mature NK T cell	7 studies	24% ± 6%	Explore
neutrophil	5 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
gamma-delta T cell	5 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
macrophage	4 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	17% ± 2%	Explore
myeloid cell	3 studies	21% ± 2%	Explore
monocyte-derived dendritic cell	3 studies	28% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADAM8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3571.72	578 / 578	94%	36.20	1088 / 1155
bladder	90%	992.38	19 / 21	91%	38.98	461 / 504
ovary	92%	466.22	165 / 180	90%	20.37	388 / 430
pancreas	84%	406.24	277 / 328	95%	58.52	169 / 178
uterus	89%	463.24	151 / 170	88%	37.74	403 / 459
breast	83%	464.18	379 / 459	87%	18.16	977 / 1118
stomach	88%	560.57	315 / 359	81%	18.15	232 / 286
intestine	79%	742.21	767 / 966	78%	17.30	409 / 527
esophagus	62%	308.39	892 / 1445	89%	24.80	162 / 183
thymus	98%	703.79	641 / 653	45%	6.17	272 / 605
kidney	93%	725.43	83 / 89	50%	6.10	449 / 901
prostate	95%	800.37	233 / 245	46%	3.80	231 / 502
skin	64%	329.61	1152 / 1809	63%	12.17	297 / 472
liver	100%	720.71	225 / 226	24%	4.20	98 / 406
lymph node	0%	0	0 / 0	100%	57.42	29 / 29
peripheral blood	100%	25820.33	929 / 929	0%	0	0 / 0
spleen	100%	7981.38	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	39.07	44 / 45
brain	61%	258.87	1610 / 2642	33%	3.99	234 / 705
adipose	90%	734.42	1080 / 1204	0%	0	0 / 0
adrenal gland	72%	323.93	186 / 258	13%	1.49	31 / 230
blood vessel	67%	531.31	896 / 1335	0%	0	0 / 0
heart	33%	149.48	280 / 861	0%	0	0 / 0
muscle	8%	26.48	63 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.28	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_0006954	Biological process	inflammatory response
GO_0051044	Biological process	positive regulation of membrane protein ectodomain proteolysis
GO_0022407	Biological process	regulation of cell-cell adhesion
GO_0070245	Biological process	positive regulation of thymocyte apoptotic process
GO_0007249	Biological process	canonical NF-kappaB signal transduction
GO_2000309	Biological process	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO_0002523	Biological process	leukocyte migration involved in inflammatory response
GO_0022617	Biological process	extracellular matrix disassembly
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0002693	Biological process	positive regulation of cellular extravasation
GO_0045089	Biological process	positive regulation of innate immune response
GO_0023061	Biological process	signal release
GO_0050714	Biological process	positive regulation of protein secretion
GO_0048247	Biological process	lymphocyte chemotaxis
GO_0006508	Biological process	proteolysis
GO_2000391	Biological process	positive regulation of neutrophil extravasation
GO_0010954	Biological process	positive regulation of protein processing
GO_0002675	Biological process	positive regulation of acute inflammatory response
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0033089	Biological process	positive regulation of T cell differentiation in thymus
GO_0000902	Biological process	cell morphogenesis
GO_2000418	Biological process	positive regulation of eosinophil migration
GO_0098609	Biological process	cell-cell adhesion
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_2000415	Biological process	positive regulation of fibronectin-dependent thymocyte migration
GO_0045780	Biological process	positive regulation of bone resorption
GO_0071456	Biological process	cellular response to hypoxia
GO_0035579	Cellular component	specific granule membrane
GO_0071133	Cellular component	alpha9-beta1 integrin-ADAM8 complex
GO_0005886	Cellular component	plasma membrane
GO_0002102	Cellular component	podosome
GO_0070820	Cellular component	tertiary granule
GO_0032127	Cellular component	dense core granule membrane
GO_0042581	Cellular component	specific granule
GO_0032010	Cellular component	phagolysosome
GO_0009986	Cellular component	cell surface
GO_0070821	Cellular component	tertiary granule membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0005737	Cellular component	cytoplasm
GO_0008237	Molecular function	metallopeptidase activity
GO_0034987	Molecular function	immunoglobulin receptor binding
GO_0032813	Molecular function	tumor necrosis factor receptor superfamily binding
GO_0008270	Molecular function	zinc ion binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	ADAM8
Protein name	ADAM8 protein (cDNA, FLJ93272, highly similar to Homo sapiens a disintegrin and metalloproteinase domain 8 (ADAM8),mRNA) Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) ADAM metallopeptidase domain 8
Synonyms	MS2
Description	FUNCTION: Possible involvement in extravasation of leukocytes.
Accessions	Q14C66 H0YKZ1 ENST00000485491.6 [P78325-2] ENST00000445355.8 [P78325-1] ENST00000415217.7 [P78325-3] P78325 H0YMT6 ENST00000560135.5 ENST00000486609.1

ADAM8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review