I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 30% ± 7% | |
| GABAergic neuron | 3 studies | 21% ± 6% | |
| plasma cell | 3 studies | 35% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 30% ± 7% | |
| GABAergic neuron | 3 studies | 21% ± 6% | |
| plasma cell | 3 studies | 35% ± 6% |
Insufficient scRNA-seq data for expression of BMP6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 91% | 399.82 | 223 / 245 | 89% | 10.36 | 447 / 502 |
| lung | 99% | 1267.84 | 575 / 578 | 70% | 8.61 | 811 / 1155 |
| kidney | 87% | 605.42 | 77 / 89 | 77% | 8.71 | 696 / 901 |
| breast | 100% | 1709.56 | 459 / 459 | 58% | 3.77 | 644 / 1118 |
| adrenal gland | 96% | 387.80 | 248 / 258 | 60% | 4.45 | 139 / 230 |
| ovary | 98% | 1106.70 | 176 / 180 | 59% | 4.94 | 252 / 430 |
| brain | 77% | 292.66 | 2034 / 2642 | 78% | 5.29 | 548 / 705 |
| thymus | 71% | 206.17 | 463 / 653 | 67% | 3.42 | 403 / 605 |
| esophagus | 79% | 283.98 | 1135 / 1445 | 57% | 3.09 | 104 / 183 |
| uterus | 94% | 435.65 | 160 / 170 | 40% | 2.76 | 182 / 459 |
| stomach | 86% | 301.59 | 307 / 359 | 44% | 2.43 | 125 / 286 |
| bladder | 81% | 349.24 | 17 / 21 | 44% | 3.14 | 222 / 504 |
| intestine | 91% | 409.63 | 876 / 966 | 32% | 1.53 | 170 / 527 |
| skin | 75% | 317.92 | 1349 / 1809 | 42% | 5.14 | 200 / 472 |
| adipose | 100% | 2033.02 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 99% | 468.19 | 239 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 93% | 721.09 | 1239 / 1335 | 0% | 0 | 0 / 0 |
| heart | 85% | 362.08 | 731 / 861 | 0% | 0 | 0 / 0 |
| muscle | 76% | 218.68 | 609 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 56% | 2.33 | 25 / 45 |
| pancreas | 1% | 2.06 | 4 / 328 | 51% | 2.45 | 90 / 178 |
| peripheral blood | 52% | 157.19 | 479 / 929 | 0% | 0 | 0 / 0 |
| liver | 26% | 73.92 | 59 / 226 | 17% | 1.97 | 71 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.33 | 3 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032349 | Biological process | positive regulation of aldosterone biosynthetic process |
| GO_0006954 | Biological process | inflammatory response |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0032026 | Biological process | response to magnesium ion |
| GO_0045603 | Biological process | positive regulation of endothelial cell differentiation |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0031666 | Biological process | positive regulation of lipopolysaccharide-mediated signaling pathway |
| GO_2000860 | Biological process | positive regulation of aldosterone secretion |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0032332 | Biological process | positive regulation of chondrocyte differentiation |
| GO_0001822 | Biological process | kidney development |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0060586 | Biological process | multicellular organismal-level iron ion homeostasis |
| GO_0001958 | Biological process | endochondral ossification |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0014823 | Biological process | response to activity |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0001654 | Biological process | eye development |
| GO_1903392 | Biological process | negative regulation of adherens junction organization |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0006955 | Biological process | immune response |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0006879 | Biological process | intracellular iron ion homeostasis |
| GO_0030539 | Biological process | male genitalia development |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_0071281 | Biological process | cellular response to iron ion |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0001501 | Biological process | skeletal system development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0060348 | Biological process | bone development |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_2000048 | Biological process | negative regulation of cell-cell adhesion mediated by cadherin |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0051216 | Biological process | cartilage development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0043117 | Biological process | positive regulation of vascular permeability |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031982 | Cellular component | vesicle |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | BMP6 |
| Protein name | BMP6 protein Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1) |
| Synonyms | VGR |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation . Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV . Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 . Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B . In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression . . |
| Accessions | P22004 A4FU97 Q4JCQ2 A1L1B5 ENST00000283147.7 Q4VBA3 A4FU96 |
