ACOD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ACOD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACOD1 at tissue level.

III. Associated gene sets

GO_0006952Biological processdefense response
GO_0006954Biological processinflammatory response
GO_0034136Biological processnegative regulation of toll-like receptor 2 signaling pathway
GO_0071219Biological processcellular response to molecule of bacterial origin
GO_0051607Biological processdefense response to virus
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0071347Biological processcellular response to interleukin-1
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0035458Biological processcellular response to interferon-beta
GO_0032480Biological processnegative regulation of type I interferon production
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0045824Biological processnegative regulation of innate immune response
GO_0050728Biological processnegative regulation of inflammatory response
GO_0002760Biological processpositive regulation of antimicrobial humoral response
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0072573Biological processtolerance induction to lipopolysaccharide
GO_0071393Biological processcellular response to progesterone stimulus
GO_0007566Biological processembryo implantation
GO_0071346Biological processcellular response to type II interferon
GO_0005739Cellular componentmitochondrion
GO_0042803Molecular functionprotein homodimerization activity
GO_0047613Molecular functionaconitate decarboxylase activity

IV. Literature review

[source]
Gene nameACOD1
Protein nameCis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)
SynonymsIRG1
DescriptionFUNCTION: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response . Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages . Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB . Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity). .

AccessionsA6NK06
ENST00000377462.6