GGT5 | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	23 studies	30% ± 17%	Explore
endothelial cell of lymphatic vessel	12 studies	31% ± 7%	Explore
pericyte	12 studies	30% ± 9%	Explore
endothelial cell	9 studies	32% ± 12%	Explore
connective tissue cell	5 studies	20% ± 4%	Explore
smooth muscle cell	5 studies	29% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GGT5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	99%	4527.60	243 / 245	98%	18.57	493 / 502
thymus	100%	9950.50	653 / 653	97%	53.33	587 / 605
breast	100%	8216.24	459 / 459	95%	26.16	1059 / 1118
lung	86%	3093.73	499 / 578	93%	21.37	1072 / 1155
adrenal gland	99%	4590.28	256 / 258	79%	18.69	182 / 230
bladder	100%	3925.48	21 / 21	75%	14.34	377 / 504
stomach	87%	2649.51	312 / 359	80%	17.63	230 / 286
kidney	93%	5849.45	83 / 89	73%	17.11	660 / 901
intestine	86%	2374.98	827 / 966	78%	14.84	409 / 527
skin	92%	4321.30	1661 / 1809	71%	10.85	337 / 472
uterus	99%	4736.97	168 / 170	63%	9.24	287 / 459
esophagus	84%	2384.18	1207 / 1445	76%	11.19	139 / 183
pancreas	55%	917.10	179 / 328	96%	54.32	171 / 178
brain	51%	975.78	1337 / 2642	99%	25.18	701 / 705
liver	89%	2221.17	201 / 226	60%	12.59	245 / 406
ovary	63%	1904.37	114 / 180	53%	6.26	230 / 430
lymph node	0%	0	0 / 0	100%	29.96	29 / 29
ureter	0%	0	0 / 0	100%	6.17	1 / 1
adipose	100%	10106.08	1203 / 1204	0%	0	0 / 0
blood vessel	99%	6880.26	1319 / 1335	0%	0	0 / 0
spleen	96%	2974.95	232 / 241	0%	0	0 / 0
heart	96%	4280.97	827 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	15.05	39 / 45
eye	0%	0	0 / 0	57%	7.18	46 / 80
muscle	49%	830.74	390 / 803	0%	0	0 / 0
peripheral blood	0%	4.16	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006954	Biological process	inflammatory response
GO_0006750	Biological process	glutathione biosynthetic process
GO_0006508	Biological process	proteolysis
GO_0006631	Biological process	fatty acid metabolic process
GO_0006520	Biological process	amino acid metabolic process
GO_0006751	Biological process	glutathione catabolic process
GO_1901750	Biological process	leukotriene D4 biosynthetic process
GO_0005886	Cellular component	plasma membrane
GO_0002951	Molecular function	leukotriene-C(4) hydrolase
GO_0103068	Molecular function	leukotriene C4 gamma-glutamyl transferase activity
GO_0000048	Molecular function	peptidyltransferase activity
GO_0036374	Molecular function	glutathione hydrolase activity

Gene name	GGT5
Protein name	Gamma-glutamyltransferase 5 Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain]
Synonyms	GGTLA1
Description	FUNCTION: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 . Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine . May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound . Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses . .
Accessions	ENST00000398292.3 [P36269-3] H7C1X2 ENST00000425408.5 P36269 ENST00000327365.10 [P36269-1] ENST00000424217.1 ENST00000263112.11 [P36269-2] C9JU68

GGT5 report