leukotriene-C(4) hydrolase

I. Literature review

[source]
Nameleukotriene-C(4) hydrolase
IDGO_0002951
collection_id

Molecular function

Description

Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate.

Comment

The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione.

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Genes