I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 6 studies | 25% ± 6% | |
| epithelial cell of proximal tubule | 4 studies | 26% ± 4% | |
| epithelial cell | 3 studies | 22% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 6 studies | 25% ± 6% | |
| epithelial cell of proximal tubule | 4 studies | 26% ± 4% | |
| epithelial cell | 3 studies | 22% ± 2% |
Insufficient scRNA-seq data for expression of GGT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 7428.87 | 89 / 89 | 65% | 1.80 | 585 / 901 |
| prostate | 98% | 1945.42 | 241 / 245 | 53% | 1.44 | 267 / 502 |
| pancreas | 100% | 2079.61 | 328 / 328 | 33% | 0.67 | 58 / 178 |
| liver | 100% | 2902.78 | 226 / 226 | 27% | 0.77 | 109 / 406 |
| intestine | 98% | 1272.82 | 950 / 966 | 23% | 0.44 | 120 / 527 |
| stomach | 97% | 1169.20 | 350 / 359 | 21% | 0.44 | 59 / 286 |
| lung | 100% | 1765.37 | 577 / 578 | 11% | 0.19 | 131 / 1155 |
| thymus | 100% | 1256.04 | 651 / 653 | 6% | 0.08 | 37 / 605 |
| bladder | 95% | 395.29 | 20 / 21 | 6% | 0.10 | 29 / 504 |
| spleen | 100% | 876.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 1722.26 | 925 / 929 | 0% | 0 | 0 / 0 |
| ovary | 94% | 328.11 | 170 / 180 | 4% | 0.05 | 16 / 430 |
| brain | 93% | 401.40 | 2460 / 2642 | 0% | 0.00 | 1 / 705 |
| breast | 80% | 467.78 | 365 / 459 | 8% | 0.18 | 92 / 1118 |
| esophagus | 73% | 272.22 | 1058 / 1445 | 13% | 0.25 | 23 / 183 |
| uterus | 80% | 256.44 | 136 / 170 | 2% | 0.04 | 11 / 459 |
| adipose | 73% | 225.76 | 884 / 1204 | 0% | 0 | 0 / 0 |
| skin | 68% | 216.20 | 1227 / 1809 | 2% | 0.03 | 9 / 472 |
| blood vessel | 70% | 205.11 | 930 / 1335 | 0% | 0 | 0 / 0 |
| heart | 49% | 192.67 | 422 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 33% | 79.95 | 84 / 258 | 0% | 0.02 | 1 / 230 |
| muscle | 15% | 40.32 | 122 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.03 | 2 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.04 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0019344 | Biological process | cysteine biosynthetic process |
| GO_0002682 | Biological process | regulation of immune system process |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0006750 | Biological process | glutathione biosynthetic process |
| GO_0031638 | Biological process | zymogen activation |
| GO_0006536 | Biological process | glutamate metabolic process |
| GO_0006691 | Biological process | leukotriene metabolic process |
| GO_0006508 | Biological process | proteolysis |
| GO_0006751 | Biological process | glutathione catabolic process |
| GO_1901750 | Biological process | leukotriene D4 biosynthetic process |
| GO_0031179 | Biological process | peptide modification |
| GO_0006520 | Biological process | amino acid metabolic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0036374 | Molecular function | glutathione hydrolase activity |
| GO_0000048 | Molecular function | peptidyltransferase activity |
| GO_0002951 | Molecular function | leukotriene-C(4) hydrolase |
| GO_0103068 | Molecular function | leukotriene C4 gamma-glutamyl transferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GGT1 |
| Protein name | GGT1 protein Gamma-glutamyltransferase 1 Gamma-glutamyltransferase (EC 2.3.2.2) Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] |
| Synonyms | GGT |
| Description | FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) . The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases . In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound . Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. .; FUNCTION: [Isoform 3]: Seems to be inactive. . |
| Accessions | ENST00000401885.5 [P19440-3] E7ETN1 ENST00000411974.5 ENST00000412658.5 Q6ISU8 ENST00000452551.5 E7ETR7 ENST00000404920.1 C9JIY6 ENST00000432867.5 E7ET76 P19440 ENST00000419133.5 ENST00000438643.6 ENST00000400382.6 [P19440-1] ENST00000451366.5 ENST00000447416.5 ENST00000430289.5 E7ERN9 ENST00000404223.5 ENST00000428855.5 B5MC36 C9JGF3 E7ESL5 B5MC34 E7ETJ6 E7ETU4 ENST00000456869.5 ENST00000445029.5 E7ENJ5 ENST00000400380.5 [P19440-1] E7EM62 ENST00000412898.5 E7EVF8 ENST00000404532.5 [P19440-3] E9PHP2 ENST00000403838.5 [P19440-3] O75693 ENST00000455483.5 A2VCM7 Q6NZY2 ENST00000425895.5 [P19440-2] |
