ANXA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001780Biological processneutrophil homeostasis
GO_0030216Biological processkeratinocyte differentiation
GO_0046883Biological processregulation of hormone secretion
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0018149Biological processpeptide cross-linking
GO_0031340Biological processpositive regulation of vesicle fusion
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0045629Biological processnegative regulation of T-helper 2 cell differentiation
GO_0050727Biological processregulation of inflammatory response
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0002250Biological processadaptive immune response
GO_0030036Biological processactin cytoskeleton organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0033031Biological processpositive regulation of neutrophil apoptotic process
GO_0002685Biological processregulation of leukocyte migration
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0006909Biological processphagocytosis
GO_0090303Biological processpositive regulation of wound healing
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0014839Biological processmyoblast migration involved in skeletal muscle regeneration
GO_0008360Biological processregulation of cell shape
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0045627Biological processpositive regulation of T-helper 1 cell differentiation
GO_0071621Biological processgranulocyte chemotaxis
GO_0045920Biological processnegative regulation of exocytosis
GO_0046632Biological processalpha-beta T cell differentiation
GO_0002548Biological processmonocyte chemotaxis
GO_0098609Biological processcell-cell adhesion
GO_0032652Biological processregulation of interleukin-1 production
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0050482Biological processarachidonic acid secretion
GO_0042119Biological processneutrophil activation
GO_0097350Biological processneutrophil clearance
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0012506Cellular componentvesicle membrane
GO_0031514Cellular componentmotile cilium
GO_0031901Cellular componentearly endosome membrane
GO_0042383Cellular componentsarcolemma
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0001533Cellular componentcornified envelope
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0001891Cellular componentphagocytic cup
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0031982Cellular componentvesicle
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005634Cellular componentnucleus
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0008289Molecular functionlipid binding
GO_0005543Molecular functionphospholipid binding
GO_0019834Molecular functionphospholipase A2 inhibitor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameANXA1
Protein nameANXA1 protein
Annexin
Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
SynonymsLPC1
ANX1
hCG_17305
DescriptionFUNCTION: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity . Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells . Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells . Has no effect on unstimulated T cells . Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton . Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes . Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). .; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades . Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors . Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration . Promotes resolution of inflammation and wound healing . Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 . .

AccessionsQ5TZZ9
ENST00000257497.11
ENST00000415424.5
ENST00000456643.5
Q05BR2
P04083
Q5T3N0
ENST00000376911.1
Q5T3N1