PLA2G2E report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLA2G2E at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G2E at tissue level.

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0006954Biological processinflammatory response
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0016042Biological processlipid catabolic process
GO_0050482Biological processarachidonic acid secretion
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0004623Molecular functionphospholipase A2 activity
GO_0005509Molecular functioncalcium ion binding
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005515Molecular functionprotein binding
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene namePLA2G2E
Protein nameGroup IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)
Synonyms
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids . Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines . In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (By similarity). May act in an autocrine and paracrine manner . Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria . Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (By similarity). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes . Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (By similarity). .

AccessionsQ9NZK7
ENST00000375116.3