IL17RC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL17RC at tissue level.

III. Associated gene sets

GO_0050832Biological processdefense response to fungus
GO_0071621Biological processgranulocyte chemotaxis
GO_0006954Biological processinflammatory response
GO_0038173Biological processinterleukin-17A-mediated signaling pathway
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0015026Molecular functioncoreceptor activity
GO_0030368Molecular functioninterleukin-17 receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL17RC
Protein nameInterleukin 17 receptor C (cDNA PSEC0233 fis, clone HEMBA1006813)
Interleukin 17 receptor C
Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)
SynonymsUNQ6118/PRO20040/PRO38901
hCG_1995707
DescriptionFUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA . Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA . Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA . Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway . Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation . Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). .; FUNCTION: [Isoform 5]: Receptor for both IL17A and IL17F. .; FUNCTION: [Isoform 6]: Does not bind IL17A or IL17F. .; FUNCTION: [Isoform 7]: Does not bind IL17A or IL17F. .; FUNCTION: [Isoform 8]: Receptor for both IL17A and IL17F. .

AccessionsENST00000412901.6
ENST00000476810.5
ENST00000696833.1
ENST00000696834.1
ENST00000455057.5 [Q8NAC3-6]
F8WD65
F8WE27
A0A8Q3SJ22
G3V177
A0A8Q3SJ19
C9K0M1
ENST00000696828.1
ENST00000383812.9 [Q8NAC3-3]
ENST00000696818.1
ENST00000696823.1
A0A8Q3WM30
A0A8Q3SJ01
ENST00000696829.1
ENST00000483582.5 [Q8NAC3-4]
ENST00000696835.1
ENST00000696832.1
A8K3Q5
ENST00000436503.6
ENST00000696836.1
ENST00000696824.1
ENST00000451231.5
ENST00000403601.8 [Q8NAC3-2]
ENST00000696826.1
ENST00000424206.5
A0A8Q3WLP4
Q8NAC3
A0A8Q3WLK4
A0A8Q3SJ61
ENST00000438091.6
ENST00000451271.5
ENST00000434756.5
A0A8Q3SIV5
ENST00000696831.1
ENST00000696837.1
F8WB43
Q8N2D7
F8WEG5
ENST00000413608.2 [Q8NAC3-5]
C9JSZ3
ENST00000498214.6
F8WC09
ENST00000696827.1
ENST00000696815.1
F6X4Z5
ENST00000696830.1
ENST00000696819.1
ENST00000295981.7 [Q8NAC3-1]
ENST00000416074.6 [Q8NAC3-7]
ENST00000696825.1
A0A8Q3WLK3
A0A8Q3SIU5
A0A8Q3SJJ9
ENST00000451165.7
A0A8Q3SJ28
ENST00000440502.5
ENST00000696816.1 [Q8NAC3-8]
B4DI24
ENST00000696822.1