IL17F report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL17F at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL17F at tissue level.

III. Associated gene sets

GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_2000340Biological processpositive regulation of chemokine (C-X-C motif) ligand 1 production
GO_0045087Biological processinnate immune response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0002225Biological processpositive regulation of antimicrobial peptide production
GO_0032677Biological processregulation of interleukin-8 production
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0032663Biological processregulation of interleukin-2 production
GO_0016525Biological processnegative regulation of angiogenesis
GO_0002250Biological processadaptive immune response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0001819Biological processpositive regulation of cytokine production
GO_0032645Biological processregulation of granulocyte macrophage colony-stimulating factor production
GO_0032675Biological processregulation of interleukin-6 production
GO_0032761Biological processpositive regulation of lymphotoxin A production
GO_0051216Biological processcartilage development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0042803Molecular functionprotein homodimerization activity
GO_0019955Molecular functioncytokine binding
GO_0005126Molecular functioncytokine receptor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL17F
Protein nameInterleukin-17F (IL-17F) (Cytokine ML-1)
Synonyms
DescriptionFUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity . IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation . IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway . Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity). .

AccessionsENST00000336123.5
Q96PD4
ENST00000699946.1