MACIR report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MACIR at tissue level.

III. Associated gene sets

GO_0010761Biological processfibroblast migration
GO_0060271Biological processcilium assembly
GO_0015031Biological processprotein transport
GO_0010633Biological processnegative regulation of epithelial cell migration
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0050728Biological processnegative regulation of inflammatory response
GO_0006954Biological processinflammatory response
GO_0010764Biological processnegative regulation of fibroblast migration
GO_0010631Biological processepithelial cell migration
GO_0035869Cellular componentciliary transition zone
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMACIR
Protein nameMacrophage immunometabolism regulator
SynonymsC5orf30
DescriptionFUNCTION: Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages . The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis . May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B . May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells . .

AccessionsENST00000515669.5
ENST00000319933.7
ENST00000510890.1
Q96GV9