PLA2G2D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLA2G2D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G2D at tissue level.

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0046337Biological processphosphatidylethanolamine metabolic process
GO_0006954Biological processinflammatory response
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0002361Biological processCD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0016042Biological processlipid catabolic process
GO_0002864Biological processregulation of acute inflammatory response to antigenic stimulus
GO_0050482Biological processarachidonic acid secretion
GO_0005576Cellular componentextracellular region
GO_0004623Molecular functionphospholipase A2 activity
GO_0043395Molecular functionheparan sulfate proteoglycan binding
GO_0008201Molecular functionheparin binding
GO_0005509Molecular functioncalcium ion binding
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene namePLA2G2D
Protein nameGroup IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)
SynonymsSPLASH
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions . Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines . In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). .

AccessionsENST00000375105.8 [Q9UNK4-1]
Q9UNK4
ENST00000617227.1 [Q9UNK4-2]