IL9 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL9 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	48%	1.98	1279 / 2642	40%	1.52	285 / 705
skin	31%	1.18	561 / 1809	1%	0.01	3 / 472
kidney	17%	0.48	15 / 89	1%	0.01	7 / 901
muscle	17%	0.69	139 / 803	0%	0	0 / 0
breast	15%	0.45	69 / 459	2%	0.08	25 / 1118
adipose	12%	0.38	147 / 1204	0%	0	0 / 0
pancreas	10%	0.26	33 / 328	1%	0.02	1 / 178
peripheral blood	8%	0.22	70 / 929	0%	0	0 / 0
esophagus	5%	1.30	78 / 1445	0%	0	0 / 183
liver	4%	0.12	10 / 226	0%	0.00	1 / 406
intestine	3%	0.13	33 / 966	0%	0.00	1 / 527
heart	3%	0.09	27 / 861	0%	0	0 / 0
stomach	2%	0.04	7 / 359	1%	0.02	3 / 286
prostate	2%	0.05	6 / 245	0%	0.01	1 / 502
spleen	2%	0.04	5 / 241	0%	0	0 / 0
thymus	2%	0.04	11 / 653	0%	0.00	1 / 605
lung	2%	0.05	9 / 578	0%	0.00	3 / 1155
blood vessel	2%	0.04	22 / 1335	0%	0	0 / 0
adrenal gland	2%	0.05	4 / 258	0%	0	0 / 230
uterus	1%	0.03	2 / 170	0%	0	0 / 459
bladder	0%	0	0 / 21	1%	0.01	4 / 504
ovary	1%	0.02	1 / 180	0%	0	0 / 430
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0050730	Biological process	regulation of peptidyl-tyrosine phosphorylation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0042100	Biological process	B cell proliferation
GO_0032754	Biological process	positive regulation of interleukin-5 production
GO_0006954	Biological process	inflammatory response
GO_0016064	Biological process	immunoglobulin mediated immune response
GO_0030307	Biological process	positive regulation of cell growth
GO_0046425	Biological process	regulation of receptor signaling pathway via JAK-STAT
GO_0030183	Biological process	B cell differentiation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005140	Molecular function	interleukin-9 receptor binding
GO_0005125	Molecular function	cytokine activity
GO_0008083	Molecular function	growth factor activity

Gene name	IL9
Protein name	Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40) Interleukin 9
Synonyms
Description	FUNCTION: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites . Affects intestinal epithelial permeability and adaptive immunity . In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. .
Accessions	Q6NZ75 Q6NZ74 P15248 ENST00000274520.2

IL9 report