CCL16 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CCL16 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCL16 at tissue level.

III. Associated gene sets

GO_0007154Biological processcell communication
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0006954Biological processinflammatory response
GO_0006935Biological processchemotaxis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007267Biological processcell-cell signaling
GO_0048245Biological processeosinophil chemotaxis
GO_0050918Biological processpositive chemotaxis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0042056Molecular functionchemoattractant activity
GO_0005515Molecular functionprotein binding
GO_0008009Molecular functionchemokine activity

IV. Literature review

[source]
Gene nameCCL16
Protein nameC-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
C-C motif chemokine
C-C motif chemokine 16 (C-C motif chemokine ligand 16)
SynonymsILINCK
NCC4
SCYA16
DescriptionFUNCTION: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

AccessionsENST00000633277.1
ENST00000610493.1
A0A087WUU4
ENST00000611905.2
O15467
ENST00000631489.1
A0A087WUE5
ENST00000621559.2
ENST00000613642.4