Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 39% ± 18% | |
| macrophage | 16 studies | 33% ± 18% | |
| endothelial cell | 15 studies | 28% ± 14% | |
| microglial cell | 14 studies | 55% ± 17% | |
| glutamatergic neuron | 10 studies | 40% ± 26% | |
| oligodendrocyte precursor cell | 10 studies | 33% ± 14% | |
| GABAergic neuron | 9 studies | 40% ± 20% | |
| dendritic cell | 9 studies | 30% ± 11% | |
| myeloid cell | 8 studies | 33% ± 12% | |
| oligodendrocyte | 8 studies | 28% ± 11% | |
| epithelial cell | 7 studies | 30% ± 12% | |
| fibroblast | 7 studies | 25% ± 9% | |
| regulatory T cell | 7 studies | 21% ± 6% | |
| CD4-positive, alpha-beta T cell | 6 studies | 20% ± 2% | |
| interneuron | 6 studies | 42% ± 22% | |
| club cell | 6 studies | 22% ± 6% | |
| monocyte | 6 studies | 30% ± 7% | |
| T cell | 6 studies | 27% ± 9% | |
| classical monocyte | 5 studies | 24% ± 5% | |
| neuron | 5 studies | 39% ± 16% | |
| type I pneumocyte | 5 studies | 23% ± 6% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 21% ± 4% | |
| granule cell | 4 studies | 23% ± 4% | |
| B cell | 4 studies | 22% ± 7% | |
| adipocyte | 4 studies | 22% ± 3% | |
| ciliated cell | 4 studies | 24% ± 6% | |
| lymphocyte | 4 studies | 30% ± 10% | |
| smooth muscle cell | 4 studies | 32% ± 13% | |
| endothelial cell of lymphatic vessel | 4 studies | 21% ± 1% | |
| type II pneumocyte | 4 studies | 18% ± 4% | |
| hematopoietic precursor cell | 3 studies | 25% ± 7% | |
| pericyte | 3 studies | 19% ± 4% | |
| GABAergic interneuron | 3 studies | 25% ± 6% | |
| glial cell | 3 studies | 23% ± 9% | |
| mononuclear phagocyte | 3 studies | 25% ± 8% | |
| CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
| basal cell | 3 studies | 27% ± 7% | |
| hepatocyte | 3 studies | 22% ± 6% | |
| abnormal cell | 3 studies | 26% ± 10% | |
| ependymal cell | 3 studies | 41% ± 21% | |
| hematopoietic stem cell | 3 studies | 22% ± 3% | |
| mast cell | 3 studies | 26% ± 7% | |
| alveolar macrophage | 3 studies | 30% ± 9% | |
| goblet cell | 3 studies | 37% ± 24% | |
| transit amplifying cell | 3 studies | 25% ± 11% | |
| mural cell | 3 studies | 30% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5898.69 | 1445 / 1445 | 100% | 59.57 | 183 / 183 |
| ovary | 100% | 5510.14 | 180 / 180 | 100% | 46.88 | 430 / 430 |
| lung | 100% | 5605.86 | 578 / 578 | 100% | 51.55 | 1154 / 1155 |
| prostate | 100% | 5726.76 | 245 / 245 | 100% | 66.20 | 501 / 502 |
| breast | 100% | 5168.88 | 459 / 459 | 100% | 68.82 | 1115 / 1118 |
| brain | 100% | 3419.52 | 2634 / 2642 | 100% | 62.81 | 704 / 705 |
| thymus | 100% | 4574.36 | 653 / 653 | 100% | 54.20 | 602 / 605 |
| pancreas | 100% | 2371.78 | 328 / 328 | 99% | 42.20 | 177 / 178 |
| intestine | 100% | 7536.30 | 966 / 966 | 99% | 41.33 | 524 / 527 |
| bladder | 100% | 6496.10 | 21 / 21 | 99% | 41.57 | 501 / 504 |
| uterus | 100% | 5537.51 | 170 / 170 | 99% | 49.10 | 456 / 459 |
| stomach | 100% | 4464.06 | 359 / 359 | 99% | 45.29 | 284 / 286 |
| kidney | 100% | 3947.02 | 89 / 89 | 97% | 37.90 | 875 / 901 |
| adrenal gland | 100% | 3757.05 | 258 / 258 | 96% | 31.92 | 220 / 230 |
| skin | 100% | 5250.22 | 1808 / 1809 | 93% | 37.89 | 440 / 472 |
| liver | 100% | 2770.19 | 226 / 226 | 90% | 24.17 | 367 / 406 |
| adipose | 100% | 5027.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6164.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 37.13 | 29 / 29 |
| muscle | 100% | 7343.66 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4325.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 50.01 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 22.50 | 1 / 1 |
| heart | 96% | 3739.42 | 825 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 96% | 3881.46 | 888 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 73% | 17.24 | 58 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007507 | Biological process | heart development |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0038061 | Biological process | non-canonical NF-kappaB signal transduction |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0043130 | Molecular function | ubiquitin binding |
| Gene name | TAB2 |
| Protein name | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) |
| Synonyms | KIAA0733 MAP3K7IP2 |
| Description | FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) . Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains . The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 . Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development . . |
| Accessions | ENST00000606797.5 ENST00000703213.1 U3KQ62 ENST00000637181.2 [Q9NYJ8-1] Q9NYJ8 ENST00000636456.1 ENST00000367456.5 [Q9NYJ8-1] A0A8V8TQR7 U3KQR0 A0A1B0GV57 ENST00000470466.5 [Q9NYJ8-2] ENST00000606202.1 |