TAB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0007507Biological processheart development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0010507Biological processnegative regulation of autophagy
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTAB2
Protein nameTGF-beta activated kinase 1 (MAP3K7) binding protein 2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
SynonymsKIAA0733
MAP3K7IP2
DescriptionFUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) . Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains . The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 . Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development . .

AccessionsENST00000606797.5
ENST00000703213.1
U3KQ62
ENST00000637181.2 [Q9NYJ8-1]
Q9NYJ8
ENST00000636456.1
ENST00000367456.5 [Q9NYJ8-1]
A0A8V8TQR7
U3KQR0
A0A1B0GV57
ENST00000470466.5 [Q9NYJ8-2]
ENST00000606202.1