IFI16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0042149Biological processcellular response to glucose starvation
GO_0045071Biological processnegative regulation of viral genome replication
GO_0006954Biological processinflammatory response
GO_2000117Biological processnegative regulation of cysteine-type endopeptidase activity
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0035458Biological processcellular response to interferon-beta
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0045824Biological processnegative regulation of innate immune response
GO_0010506Biological processregulation of autophagy
GO_0030099Biological processmyeloid cell differentiation
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0043392Biological processnegative regulation of DNA binding
GO_0002218Biological processactivation of innate immune response
GO_0006914Biological processautophagy
GO_0001819Biological processpositive regulation of cytokine production
GO_0071479Biological processcellular response to ionizing radiation
GO_0030224Biological processmonocyte differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFI16
Protein nameInterferon gamma inducible protein 16
Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)
SynonymsIFNGIP1
DescriptionFUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome . Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 . Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome . This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 . .

AccessionsQ16666
H3BR65
H3BR88
ENST00000474473.1
ENST00000295809.12 [Q16666-1]
X6RHM1
ENST00000368132.7 [Q16666-2]
ENST00000566111.5
ENST00000447473.6
H3BM18
ENST00000426592.6
H3BVE6
ENST00000567661.5
ENST00000359709.7 [Q16666-6]
ENST00000368131.8 [Q16666-2]
ENST00000448393.6 [Q16666-3]