TNIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050871Biological processpositive regulation of B cell activation
GO_0023035Biological processCD40 signaling pathway
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0006954Biological processinflammatory response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0043032Biological processpositive regulation of macrophage activation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0050821Biological processprotein stabilization
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0034134Biological processtoll-like receptor 2 signaling pathway
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNIP2
Protein nameTNFAIP3 interacting protein 2
TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)
SynonymsABIN2
FLIP1
DescriptionFUNCTION: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. .

AccessionsENST00000503235.1
Q8NFZ5
D6RGJ2
ENST00000510267.5 [Q8NFZ5-2]
ENST00000315423.12 [Q8NFZ5-1]