RPS6KA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0006954Biological processinflammatory response
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0035556Biological processintracellular signal transduction
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001818Biological processnegative regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007411Biological processaxon guidance
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0099175Biological processregulation of postsynapse organization
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0044022Molecular functionhistone H3S28 kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0044024Molecular functionhistone H2AS1 kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0035175Molecular functionhistone H3S10 kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS6KA5
Protein nameRibosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Ribosomal protein S6 kinase A5
SynonymsMSK1
DescriptionFUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes . Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin . Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression . In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress . In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential . Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation . Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A . Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN . May also phosphorylate 'Ser-28' of histone H3 . Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) . In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity . .

AccessionsENST00000556594.1
ENST00000554206.1
ENST00000614987.5 [O75582-1]
H0YJE1
ENST00000418736.6 [O75582-2]
G3V2D1
ENST00000648062.1
A0A3B3ISL8
G3V4D7
O75582
ENST00000556178.5
ENST00000536315.6 [O75582-3]