Name | Number of supported studies | Average coverage | |
---|---|---|---|
mast cell | 21 studies | 39% ± 20% | |
oligodendrocyte | 13 studies | 37% ± 12% | |
astrocyte | 12 studies | 33% ± 15% | |
glutamatergic neuron | 9 studies | 44% ± 19% | |
endothelial cell | 9 studies | 31% ± 15% | |
microglial cell | 8 studies | 23% ± 7% | |
B cell | 7 studies | 26% ± 8% | |
CD4-positive, alpha-beta T cell | 7 studies | 21% ± 5% | |
macrophage | 6 studies | 29% ± 1% | |
epithelial cell | 6 studies | 41% ± 21% | |
ciliated cell | 6 studies | 35% ± 18% | |
neuron | 5 studies | 32% ± 12% | |
T cell | 5 studies | 24% ± 7% | |
GABAergic neuron | 5 studies | 40% ± 12% | |
granule cell | 4 studies | 37% ± 10% | |
interneuron | 4 studies | 47% ± 18% | |
lymphocyte | 4 studies | 33% ± 11% | |
oligodendrocyte precursor cell | 4 studies | 23% ± 9% | |
monocyte | 4 studies | 26% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 21% ± 3% | |
myeloid cell | 3 studies | 20% ± 5% | |
GABAergic amacrine cell | 3 studies | 31% ± 4% | |
glycinergic amacrine cell | 3 studies | 27% ± 4% | |
retina horizontal cell | 3 studies | 20% ± 2% | |
basal cell | 3 studies | 40% ± 24% | |
amacrine cell | 3 studies | 24% ± 4% | |
retinal rod cell | 3 studies | 16% ± 1% | |
transit amplifying cell | 3 studies | 43% ± 31% | |
regulatory T cell | 3 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2382.43 | 1441 / 1445 | 89% | 2.49 | 163 / 183 |
brain | 100% | 2200.82 | 2634 / 2642 | 82% | 2.20 | 578 / 705 |
breast | 97% | 1274.58 | 445 / 459 | 84% | 2.38 | 940 / 1118 |
prostate | 100% | 1078.55 | 245 / 245 | 74% | 1.41 | 370 / 502 |
stomach | 100% | 1594.62 | 359 / 359 | 72% | 1.47 | 207 / 286 |
uterus | 100% | 1323.49 | 170 / 170 | 71% | 1.94 | 324 / 459 |
lung | 97% | 677.10 | 558 / 578 | 70% | 1.58 | 805 / 1155 |
intestine | 100% | 2105.97 | 966 / 966 | 65% | 1.22 | 343 / 527 |
bladder | 100% | 1747.33 | 21 / 21 | 58% | 1.28 | 293 / 504 |
skin | 73% | 854.48 | 1329 / 1809 | 82% | 2.72 | 388 / 472 |
ovary | 100% | 1016.76 | 180 / 180 | 39% | 0.57 | 166 / 430 |
thymus | 99% | 822.86 | 648 / 653 | 25% | 0.48 | 151 / 605 |
spleen | 100% | 951.44 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 99% | 1242.50 | 794 / 803 | 0% | 0 | 0 / 0 |
adipose | 95% | 698.01 | 1144 / 1204 | 0% | 0 | 0 / 0 |
kidney | 55% | 279.19 | 49 / 89 | 35% | 0.57 | 317 / 901 |
pancreas | 56% | 228.87 | 183 / 328 | 33% | 0.58 | 59 / 178 |
tonsil | 0% | 0 | 0 / 0 | 87% | 2.15 | 39 / 45 |
heart | 77% | 470.71 | 666 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 70% | 361.65 | 934 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 54% | 317.29 | 503 / 929 | 0% | 0 | 0 / 0 |
adrenal gland | 19% | 71.02 | 50 / 258 | 32% | 0.54 | 74 / 230 |
eye | 0% | 0 | 0 / 0 | 18% | 0.24 | 14 / 80 |
lymph node | 0% | 0 | 0 / 0 | 17% | 0.23 | 5 / 29 |
liver | 9% | 28.22 | 20 / 226 | 4% | 0.08 | 18 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032793 | Biological process | positive regulation of CREB transcription factor activity |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0006954 | Biological process | inflammatory response |
GO_0070498 | Biological process | interleukin-1-mediated signaling pathway |
GO_0043687 | Biological process | post-translational protein modification |
GO_0006338 | Biological process | chromatin remodeling |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0001818 | Biological process | negative regulation of cytokine production |
GO_0006468 | Biological process | protein phosphorylation |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0007411 | Biological process | axon guidance |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0099175 | Biological process | regulation of postsynapse organization |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0044022 | Molecular function | histone H3S28 kinase activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0044024 | Molecular function | histone H2AS1 kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0035175 | Molecular function | histone H3S10 kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | RPS6KA5 |
Protein name | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) Ribosomal protein S6 kinase A5 |
Synonyms | MSK1 |
Description | FUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes . Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin . Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression . In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress . In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential . Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation . Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A . Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN . May also phosphorylate 'Ser-28' of histone H3 . Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) . In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity . . |
Accessions | ENST00000556594.1 ENST00000554206.1 ENST00000614987.5 [O75582-1] H0YJE1 ENST00000418736.6 [O75582-2] G3V2D1 ENST00000648062.1 A0A3B3ISL8 G3V4D7 O75582 ENST00000556178.5 ENST00000536315.6 [O75582-3] |