AXL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035457Biological processcellular response to interferon-alpha
GO_0007283Biological processspermatogenesis
GO_0001974Biological processblood vessel remodeling
GO_0006954Biological processinflammatory response
GO_0048549Biological processpositive regulation of pinocytosis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0001779Biological processnatural killer cell differentiation
GO_0051250Biological processnegative regulation of lymphocyte activation
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0001961Biological processpositive regulation of cytokine-mediated signaling pathway
GO_0048678Biological processresponse to axon injury
GO_0007275Biological processmulticellular organism development
GO_1903902Biological processpositive regulation of viral life cycle
GO_0001764Biological processneuron migration
GO_0031100Biological processanimal organ regeneration
GO_0042698Biological processovulation cycle
GO_0097028Biological processdendritic cell differentiation
GO_0051649Biological processestablishment of localization in cell
GO_0030168Biological processplatelet activation
GO_0032940Biological processsecretion by cell
GO_0034101Biological processerythrocyte homeostasis
GO_0033674Biological processpositive regulation of kinase activity
GO_0046718Biological processsymbiont entry into host cell
GO_0032825Biological processpositive regulation of natural killer cell differentiation
GO_0051402Biological processneuron apoptotic process
GO_0060068Biological processvagina development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0006909Biological processphagocytosis
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0021885Biological processforebrain cell migration
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0032689Biological processnegative regulation of type II interferon production
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007399Biological processnervous system development
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_2000669Biological processnegative regulation of dendritic cell apoptotic process
GO_0048469Biological processcell maturation
GO_0016477Biological processcell migration
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0097350Biological processneutrophil clearance
GO_0005615Cellular componentextracellular space
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0015629Cellular componentactin cytoskeleton
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0032036Molecular functionmyosin heavy chain binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0001618Molecular functionvirus receptor activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAXL
Protein nameTyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
receptor protein-tyrosine kinase (EC 2.7.10.1)
SynonymsUFO
DescriptionFUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. .; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. .; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. .; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes . Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection . Interferon signaling inhibition occurs via an SOCS1-dependent mechanism . .

AccessionsP30530
ENST00000301178.9 [P30530-1]
ENST00000359092.7 [P30530-2]
ENST00000593513.1
M0R0W6