Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 17 studies | 39% ± 21% | |
B cell | 15 studies | 32% ± 15% | |
microglial cell | 15 studies | 61% ± 16% | |
oligodendrocyte | 14 studies | 36% ± 16% | |
oligodendrocyte precursor cell | 14 studies | 46% ± 17% | |
glutamatergic neuron | 13 studies | 56% ± 24% | |
dendritic cell | 13 studies | 39% ± 21% | |
conventional dendritic cell | 12 studies | 26% ± 13% | |
GABAergic neuron | 11 studies | 56% ± 24% | |
endothelial cell | 10 studies | 34% ± 14% | |
neuron | 7 studies | 38% ± 16% | |
astrocyte | 7 studies | 32% ± 23% | |
naive B cell | 7 studies | 20% ± 3% | |
myeloid cell | 7 studies | 41% ± 15% | |
interneuron | 6 studies | 60% ± 30% | |
retina horizontal cell | 6 studies | 47% ± 25% | |
monocyte | 6 studies | 32% ± 15% | |
epithelial cell | 5 studies | 39% ± 28% | |
cardiac muscle cell | 5 studies | 59% ± 14% | |
pericyte | 5 studies | 25% ± 7% | |
smooth muscle cell | 5 studies | 31% ± 14% | |
plasma cell | 4 studies | 32% ± 10% | |
vein endothelial cell | 4 studies | 58% ± 13% | |
retinal bipolar neuron | 4 studies | 50% ± 27% | |
ON-bipolar cell | 4 studies | 69% ± 27% | |
amacrine cell | 4 studies | 60% ± 18% | |
retinal cone cell | 4 studies | 38% ± 15% | |
retinal ganglion cell | 4 studies | 81% ± 21% | |
retinal rod cell | 4 studies | 49% ± 12% | |
plasmacytoid dendritic cell | 4 studies | 26% ± 6% | |
GABAergic interneuron | 3 studies | 59% ± 10% | |
immature B cell | 3 studies | 21% ± 2% | |
mononuclear phagocyte | 3 studies | 36% ± 23% | |
GABAergic amacrine cell | 3 studies | 38% ± 15% | |
OFF-bipolar cell | 3 studies | 72% ± 15% | |
glycinergic amacrine cell | 3 studies | 55% ± 12% | |
rod bipolar cell | 3 studies | 63% ± 27% | |
endothelial cell of vascular tree | 3 studies | 26% ± 8% | |
natural killer cell | 3 studies | 20% ± 4% | |
granule cell | 3 studies | 47% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 96% | 1175.01 | 2539 / 2642 | 99% | 6.50 | 696 / 705 |
prostate | 98% | 1257.60 | 240 / 245 | 85% | 5.27 | 426 / 502 |
thymus | 93% | 653.47 | 608 / 653 | 87% | 3.82 | 525 / 605 |
breast | 98% | 1351.89 | 450 / 459 | 67% | 3.10 | 754 / 1118 |
uterus | 99% | 2222.02 | 169 / 170 | 56% | 3.12 | 257 / 459 |
esophagus | 77% | 2156.91 | 1115 / 1445 | 76% | 4.05 | 139 / 183 |
lung | 81% | 448.48 | 468 / 578 | 72% | 3.16 | 833 / 1155 |
skin | 88% | 930.02 | 1583 / 1809 | 53% | 2.27 | 250 / 472 |
intestine | 93% | 988.36 | 903 / 966 | 38% | 1.34 | 198 / 527 |
bladder | 90% | 669.62 | 19 / 21 | 37% | 1.11 | 184 / 504 |
ovary | 32% | 192.43 | 57 / 180 | 93% | 4.48 | 398 / 430 |
adrenal gland | 43% | 232.75 | 112 / 258 | 73% | 8.61 | 168 / 230 |
kidney | 43% | 231.25 | 38 / 89 | 71% | 1.77 | 641 / 901 |
stomach | 55% | 936.54 | 196 / 359 | 51% | 2.17 | 146 / 286 |
spleen | 100% | 1403.90 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2157.04 | 1328 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 1437.89 | 1193 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 11% | 43.95 | 35 / 328 | 86% | 2.91 | 153 / 178 |
heart | 90% | 741.18 | 774 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 4.73 | 25 / 29 |
tonsil | 0% | 0 | 0 / 0 | 58% | 1.36 | 26 / 45 |
muscle | 53% | 471.57 | 424 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 42% | 386.84 | 393 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 26% | 0.61 | 21 / 80 |
liver | 0% | 2.00 | 1 / 226 | 13% | 0.36 | 53 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048742 | Biological process | regulation of skeletal muscle fiber development |
GO_0045814 | Biological process | negative regulation of gene expression, epigenetic |
GO_0006954 | Biological process | inflammatory response |
GO_0032869 | Biological process | cellular response to insulin stimulus |
GO_0007507 | Biological process | heart development |
GO_0051153 | Biological process | regulation of striated muscle cell differentiation |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0090050 | Biological process | positive regulation of cell migration involved in sprouting angiogenesis |
GO_0030182 | Biological process | neuron differentiation |
GO_0034983 | Biological process | peptidyl-lysine deacetylation |
GO_0042113 | Biological process | B cell activation |
GO_0001818 | Biological process | negative regulation of cytokine production |
GO_0001975 | Biological process | response to amphetamine |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0030183 | Biological process | B cell differentiation |
GO_0042632 | Biological process | cholesterol homeostasis |
GO_0035097 | Cellular component | histone methyltransferase complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000118 | Cellular component | histone deacetylase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0005080 | Molecular function | protein kinase C binding |
GO_0033558 | Molecular function | protein lysine deacetylase activity |
GO_0140297 | Molecular function | DNA-binding transcription factor binding |
GO_0004407 | Molecular function | histone deacetylase activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0031078 | Molecular function | histone H3K14 deacetylase activity |
GO_0034739 | Molecular function | histone H4K16 deacetylase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0032129 | Molecular function | histone H3K9 deacetylase activity |
GO_0005515 | Molecular function | protein binding |
GO_0042826 | Molecular function | histone deacetylase binding |
Gene name | HDAC9 |
Protein name | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) histone deacetylase (EC 3.5.1.98) Uncharacterized protein HDAC9 Histone deacetylase 9 |
Synonyms | KIAA0744 HDAC7B MITR HDRP HDAC7 |
Description | FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. .; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
Accessions | A0A7P0T8F4 ENST00000441542.7 [Q9UKV0-7] C9JD56 Q75N10 ENST00000413509.6 ENST00000417496.6 [Q9UKV0-8] Q9UKV0 A0A9L9PY57 Q75N09 C9IZS0 ENST00000441986.5 ENST00000686413.1 [Q9UKV0-7] F8WDS2 ENST00000446646.1 ENST00000707082.1 ENST00000406072.5 ENST00000681950.1 ENST00000707080.1 ENST00000430454.5 ENST00000456174.6 [Q9UKV0-10] Q75N14 A0A7P0TAB5 B7Z3P7 ENST00000406451.8 [Q9UKV0-5] ENST00000432645.6 [Q9UKV0-1] ENST00000622668.4 Q75N15 C9JLX1 ENST00000401921.5 [Q9UKV0-6] ENST00000524023.1 [Q9UKV0-11] ENST00000405010.7 [Q9UKV0-3] ENST00000433709.6 C9J835 A0A9L9PXM4 ENST00000428307.6 [Q9UKV0-9] A0A9L9PXL9 ENST00000707077.1 ENST00000413380.5 ENST00000681273.1 A0A9L9PY89 C9J1W4 Q75N16 Q9Y6V1 ENST00000707081.1 B5MCF1 Q75N08 |