HDAC9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048742Biological processregulation of skeletal muscle fiber development
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0006954Biological processinflammatory response
GO_0032869Biological processcellular response to insulin stimulus
GO_0007507Biological processheart development
GO_0051153Biological processregulation of striated muscle cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0030182Biological processneuron differentiation
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_0042113Biological processB cell activation
GO_0001818Biological processnegative regulation of cytokine production
GO_0001975Biological processresponse to amphetamine
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030183Biological processB cell differentiation
GO_0042632Biological processcholesterol homeostasis
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0005737Cellular componentcytoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0031078Molecular functionhistone H3K14 deacetylase activity
GO_0034739Molecular functionhistone H4K16 deacetylase activity
GO_0046872Molecular functionmetal ion binding
GO_0032129Molecular functionhistone H3K9 deacetylase activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC9
Protein nameHistone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
histone deacetylase (EC 3.5.1.98)
Uncharacterized protein HDAC9
Histone deacetylase 9
SynonymsKIAA0744
HDAC7B
MITR
HDRP
HDAC7
DescriptionFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. .; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

AccessionsA0A7P0T8F4
ENST00000441542.7 [Q9UKV0-7]
C9JD56
Q75N10
ENST00000413509.6
ENST00000417496.6 [Q9UKV0-8]
Q9UKV0
A0A9L9PY57
Q75N09
C9IZS0
ENST00000441986.5
ENST00000686413.1 [Q9UKV0-7]
F8WDS2
ENST00000446646.1
ENST00000707082.1
ENST00000406072.5
ENST00000681950.1
ENST00000707080.1
ENST00000430454.5
ENST00000456174.6 [Q9UKV0-10]
Q75N14
A0A7P0TAB5
B7Z3P7
ENST00000406451.8 [Q9UKV0-5]
ENST00000432645.6 [Q9UKV0-1]
ENST00000622668.4
Q75N15
C9JLX1
ENST00000401921.5 [Q9UKV0-6]
ENST00000524023.1 [Q9UKV0-11]
ENST00000405010.7 [Q9UKV0-3]
ENST00000433709.6
C9J835
A0A9L9PXM4
ENST00000428307.6 [Q9UKV0-9]
A0A9L9PXL9
ENST00000707077.1
ENST00000413380.5
ENST00000681273.1
A0A9L9PY89
C9J1W4
Q75N16
Q9Y6V1
ENST00000707081.1
B5MCF1
Q75N08