CEBPB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0050873Biological processbrown fat cell differentiation
GO_0006953Biological processacute-phase response
GO_2001198Biological processregulation of dendritic cell differentiation
GO_0006954Biological processinflammatory response
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_2000120Biological processpositive regulation of sodium-dependent phosphate transport
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0001892Biological processembryonic placenta development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001541Biological processovarian follicle development
GO_0070169Biological processpositive regulation of biomineral tissue development
GO_0140467Biological processintegrated stress response signaling
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0045670Biological processregulation of osteoclast differentiation
GO_0006955Biological processimmune response
GO_0030182Biological processneuron differentiation
GO_0097421Biological processliver regeneration
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045595Biological processregulation of cell differentiation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_1901329Biological processregulation of odontoblast differentiation
GO_0060644Biological processmammary gland epithelial cell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0071230Biological processcellular response to amino acid stimulus
GO_0072574Biological processhepatocyte proliferation
GO_0042742Biological processdefense response to bacterium
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0050729Biological processpositive regulation of inflammatory response
GO_0032675Biological processregulation of interleukin-6 production
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0061515Biological processmyeloid cell development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_1990647Cellular componentC/EBP complex
GO_0036488Cellular componentCHOP-C/EBP complex
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0019900Molecular functionkinase binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameCEBPB
Protein nameCEBPB protein
CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
Transcription factor C/EBP beta
SynonymsPP9092
TCF5
DescriptionFUNCTION: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses . Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation . Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). .; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. .; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 . Promotes osteoblast differentiation and osteoclastogenesis (By similarity). .

AccessionsQ9BSC0
W8SNU6
W8SNV5
ENST00000303004.5 [P17676-1]
P17676