NLRP4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP4 at tissue level.

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0006954Biological processinflammatory response
GO_0050727Biological processregulation of inflammatory response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0060090Molecular functionmolecular adaptor activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNLRP4
Protein nameNLR family pyrin domain containing 4
NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)
SynonymsNALP4
PAN2
RNH2
PYPAF4
DescriptionFUNCTION: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. .

AccessionsENST00000587891.5 [Q96MN2-3]
Q96MN2
K7ES09
ENST00000589437.1
ENST00000301295.11 [Q96MN2-1]
ENST00000587464.1
K7ESK5